Results 261 to 270 of about 185,382 (296)
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Cyclin-dependent kinase-5 targeting for ischaemic stroke
Current Opinion in Pharmacology, 2009Recovery from ischaemic stroke is dependent on survival of neurones, particularly in peri-infarcted regions. Angiogenesis is critical for the development of new microvessels resulting in the re-formation of collateral circulation associated with enhanced neuronal survival and reduced morbidity and mortality.
Mark, Slevin, Jerzy, Krupinski
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Cyclin-Dependent Kinase 5--A Neuronal Killer?
Science of Aging Knowledge Environment, 2003In dividing cells, cyclin-dependent kinases (Cdks) are cell cycle-associated protein kinases that regulate proliferation, differentiation, senescence, and apoptosis. In neurons that no longer divide, deregulation of Cdks, especially Cdk5, occurs in many neurological disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD).
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Cyclin Dependent Kinase 5 (Cdk5)
2008Neuronsmigrate from proliferative zone to their final position during brain development. Cyclin-dependent kinase 5 (Cdk5) plays an important role in neuronal migration to establish a proper structure of the brain. Analyses of Cdk5/p35-deficient mice have provided the knowledge about the role of Cdk5/p35 in neuronal migration.
Ip, Nancy Yuk-Yu LIFS, Tsai, Li-Huei
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Cyclin-dependent kinase 5 immunoreactivity for granulovacuolar degeneration
NeuroReport, 2012In addition to senile plaque and neurofibrillary tangles, granulovacuolar degeneration is a hallmark of Alzheimer's disease. A number of tau kinases, such as c-jun N-terminal kinase (JNK), glycogen-synthase kinase-3β (GSK3β), and casein kinase 1 (CK1), have been reported to be markers of granulovacuolar degeneration.
Masahiro, Nakamori +5 more
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Modulation of Reelin signaling by Cyclin-dependent kinase 5
Brain Research, 2007The Reelin signaling and Cyclin-dependent kinase 5 (Cdk5) both regulate neuronal positioning in the developing brain. Using double-transgenic mice, we have previously shown that these two signaling pathways lie in parallel fashion and have a genetic interaction.
Toshio, Ohshima +4 more
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The roles of cyclin‐dependent kinase 5 in dendrite and synapse development
Biotechnology Journal, 2007AbstractSince the isolation of cyclin‐dependent kinase 5 (Cdk5), this proline‐directed serine/threonine kinase has been demonstrated as an important regulator of neuronal migration, neuronal survival and synaptic functions. Recently, a number of players implicated in dendrite and synapse development have been identified as Cdk5 substrates.
Ip, NY, Cheung, ZH
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Cyclin-dependent kinases 5 template: Useful for virtual screening
Computers in Biology and Medicine, 2012The present study reports the development of a template for the active binding site of Cdk5 for structure-based drug design. The developed template of Cdk5 was validated by redocking with ligands I (PBD code 1UNG), II (PBD code 1UNL) and III (PBD code 1UNH).
Siripit Pitchuanchom +4 more
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Reelin and Cyclin-Dependent Kinase 5
2008Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter,
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Role of cyclin-dependent kinase 5 in capsaicin-induced cough
European Journal of Pharmacology, 2007The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice. Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced coughs in a concentration-dependent manner.
Junzo, Kamei +3 more
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Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium
Neuroscience, 2005Although numerous studies have demonstrated a neuroprotective and anti-apoptotic role of lithium in neuronal cell cultures, the precise mechanism by which this occurs, remains to be elucidated. In this study, we evaluated the lithium-mediated neuroprotection against colchicine-induced apoptosis in cultured cerebellar granule neurons. Previously, it has
E G, Jordà +7 more
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