Results 221 to 230 of about 2,935,830 (275)

Effects of Roscovitine and Serum Starvation on the Viability and G0/G1 Synchronization in Somatic Cells from the Antillean Manatee (Trichechus manatus manatus, Linnaeus 1758)

Zoo Biology, EarlyView.
ABSTRACT The success of nuclear reprogramming techniques, including the G0/G1 synchronization of somatic cells, depends on species‐specific optimization. While roscovitine and serum starvation have been successfully applied in domestic and wild terrestrial mammals, their use in aquatic mammals remains poorly investigated.
Luanna Lorenna Vieira Rodrigues, Leonardo Vitorino Costa de Aquino, Lhara Ricarliany Medeiros de Oliveira, João Vitor da Silva Viana, Sarah Sant'Anna Maranhão, Maria Claudia dos Santos Luciano, Radan Elvis Matias de Oliveira, Fábia Oliveira Luna, Fernanda Loffler Niemeyer Attademo, Claudia Pessoa, Alexsandra Fernandes Pereira   +10 more
wiley   +1 more source

Local Low‐Frequency Vibration Enhances Wound‐Healing and Modulates Cellular Senescence in Tissues and Exudates in a Hyperglycemic Rat Model

The Journal of Dermatology, EarlyView.
ABSTRACT Hard‐to‐heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence‐associated mechanisms, including stress‐responsive p53/p21 signaling and senescence‐associated secretory phenotype‐related inflammation, contribute to impaired wound ...
Daijiro Haba, Chihiro Takizawa, Qi Qin, Sanai Tomida, Ai Horinouchi, Hiromi Sanada, Gojiro Nakagami   +6 more
wiley   +1 more source

Palbociclib in the Treatment of HR+/ HER2‐ Advanced or Metastatic Breast Cancer in Australia: A Real‐World Retrospective Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This study investigated the real‐world use of CDK4/6 inhibitors in Australian patients with HR+/HER2‐ advanced or metastatic breast cancer, providing data on patient demographics, treatment patterns, and outcomes with palbociclib. ABSTRACT Background There is limited real‐world data on the use of CDK4/6 inhibitors in Australian patients with HR+/HER2 ...
Louise Nott, Eugene Moylan, Maree Colosimo, Giles Stratton, Thomas Chiu, Mahsa H. Kouhkamari, Maureen Hitschfeld, Jessica Michie, Richard De Boer   +8 more
wiley   +1 more source

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Expression of cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors in oligodendrogliomas in humans

Neuroscience Letters, 2003
Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4-6, CDK2, Cdc2 and p27/Kip.1 have ...
Valentina Fiano
exaly   +3 more sources

Cyclin-Dependent Kinases

Chemical Reviews, 2001
Harper Jw, P D Adams
exaly   +4 more sources

Cdk Pathway: Cyclin-Dependent Kinases and Cyclin-Dependent Kinase Inhibitors

Molecular Biotechnology, 2001
Many mechanisms either activate or inhibit the cdks and thereby either promote or arrest progression through the mitotic cell cycle. Since the signal transduction pathways emanating from extracellular mitogens and the agents controlling these pathways are complicated there may yet be novel mechanisms of cell cycle regulation remaining to be elucidated.
D M, Gitig, A, Koff
openaire   +3 more sources

Cyclin-dependent kinase inhibitors.

Progress in cell cycle research, 2003
Cyclin-dependent kinases are involved in diverse cellular processes that include cell cycle control, apoptosis, neuronal physiology, differentiation, and transcription. Intensive screening and drug design based on CDK/inhibitor co-crystal structures and on SAR studies have led to the identification and characterization of a large variety of chemical ...
P. M., Fischer, Endicott, J., Meijer, L.
openaire   +5 more sources

Cyclin-dependent kinases and stroke

Expert Opinion on Therapeutic Targets, 2001
Cyclin-dependent kinases (CDKs) are a group of enzymes predominately known for their role in cell cycle regulation in proliferating cell types. Increasing evidence, however, suggests that CDKs also promote death in neurones. These observations have lead to the notion that CDKs may serve as a therapeutic target for neuropathological conditions such as ...
Fuhu, Wang, Michael J, O'Hare, David S, Park   +2 more
openaire   +2 more sources

Mammalian cyclin-dependent kinases

Trends in Biochemical Sciences, 2005
Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function. Recent genetic evidence obtained with gene-targeted mice has shown that Cdk4 and Cdk6 are not needed for entry into the cell ...
Marcos, Malumbres, Mariano, Barbacid
openaire   +2 more sources

The discovery of cyclin-dependent kinases

Nature Reviews Molecular Cell Biology
exaly   +3 more sources