Results 281 to 290 of about 382,305 (392)

Genetic variants linked to type 2 diabetes in CDKN1B and TCF7L2 influence survival outcomes in metastatic colorectal cancer

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Multiple genetic polymorphisms characteristic of type 2 diabetes (T2D) have been associated with unfavorable prognostic outcomes in individuals with both T2D and metastatic colorectal cancer. This study evaluated the impact of T2D genetic polymorphisms on metastatic colon cancer prognosis in a cohort of non‐diabetic patients.
Raffaella Ruggiero   +11 more
wiley   +1 more source

Genetic Status and Expression of the Cyclin‐dependent Kinase Inhibitors in Human Gastric Carcinoma Cell Lines [PDF]

open access: hybrid, 1996
Yoshihiko Akama   +7 more
openalex   +1 more source

Diagnosis and management of gestational trophoblastic disease: 2025 update

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Gestational trophoblastic disease (GTD) arises from abnormal placenta and comprises a spectrum of premalignant to malignant disorders. Changes in the epidemiology of GTD have been noted in various countries. In addition to histology, molecular genetic studies can help in the diagnostic pathway.
Hextan Y. S. Ngan   +7 more
wiley   +1 more source

Prostaglandin A2 Blocks the Activation of G1 Phase Cyclin-dependent Kinase without Altering Mitogen-activated Protein Kinase Stimulation [PDF]

open access: hybrid, 1996
Masahiro Hitomi   +5 more
openalex   +1 more source

Current Progress in Targeting Human Cytomegalovirus Infection

open access: yesiLABMED, EarlyView.
This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection.
Yonggang Pei, Jun Chen
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

open access: yesiMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu   +8 more
wiley   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

open access: yesInterdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li   +5 more
wiley   +1 more source

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