Results 261 to 270 of about 114,587 (298)

Designing Inhibitors of Cyclin-Dependent Kinases

Annual Review of Pharmacology and Toxicology, 2002
Cyclin-dependent kinases (cdks) play a pivotal role in controlling progression through the cell cycle. The complex mechanisms that control cdks have been elucidated and, in the case of cdk2, explained with reference to X-ray crystal structures of the catalytically active and inactive kinase.
Ian R, Hardcastle, Bernard T, Golding, Roger J, Griffin   +2 more
openaire   +2 more sources

Cyclin-Dependent Kinase Inhibition by Flavoalkaloids

Mini-Reviews in Medicinal Chemistry, 2012
Chromone alkaloids and flavoalkaloids are an important group of natural products possessing promising medicinal properties. A chromone alkaloid rohitukine is a major bioactive chemical constituent of plant Dysoxylum binectariferum (Meliaceae) Hook. which is phylogenetically related to the Ayurvedic plant, D. malabaricum Bedd.
S K, Jain, S B, Bharate, R A, Vishwakarma   +2 more
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Quinazolines as cyclin dependent kinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2001
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
T M, Sielecki, T L, Johnson, J, Liu, J K, Muckelbauer, R H, Grafstrom, S, Cox, J, Boylan, C R, Burton, H, Chen, A, Smallwood, C H, Chang, M, Boisclair, P A, Benfield, G L, Trainor, S P, Seitz   +14 more
openaire   +2 more sources

Targets of the cyclin-dependent kinase Cdk1

Nature, 2003
The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of phosphate from ATP to specific protein substrates. Despite their importance in cell-cycle control, few Cdk substrates have been identified.
Jeffrey A, Ubersax, Erika L, Woodbury, Phuong N, Quang, Maria, Paraz, Justin D, Blethrow, Kavita, Shah, Kevan M, Shokat, David O, Morgan   +7 more
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Identification of substrates for cyclin dependent kinases

Advances in Enzyme Regulation, 2010
Protein phosphorylation is a key regulatory mechanism for cell cycle control in eukaryotes. From yeast to humans, cell cycle progression and cell division require the activation of a group of serine– threonine protein kinases called cyclin dependent kinases (CDKs) (Morgan, 1997), which initiate and coordinate these processes by orderly phosphorylation ...
Errico, A., Deshmukh, K., Tanaka, Y., Pozniakovsky, A., Hunt, T.   +4 more
openaire   +3 more sources

Cyclins, cyclin‐dependent kinases and differentiation

BioEssays, 1997
AbstractCyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non‐cycling, differentiated cells. This review surveys the available information about cyclins and cyclin‐dependent kinases in differentiated cells and explores the ...
C Y, Gao, P S, Zelenka
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Chemical inhibitors of cyclin-dependent kinases

Trends in Cell Biology, 1995
The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk's is responsible for transition through the different phases of the cell cycle.
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p27KIP1, an inhibitor of cyclin-dependent kinases

1995
The identification of a family of proteins that stoichiometrically regulate the activation of the G1 cyclin-dependent kinases has added to our understanding of the process of commitment to the mitotic cycle. The properties of p27 as a CDK binding protein, the ability of environmental signals to regulate the expression of p27, and the observation that ...
A, Koff, K, Polyak
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Smad3 phosphorylation by cyclin-dependent kinases

Cytokine & Growth Factor Reviews, 2006
Smad3, a key mediator for TGF-beta antiproliferative responses, is phosphorylated by both CDK4 and CDK2 in vivo and in vitro. Except for the Rb family members, Smad3 is the only CDK4 substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function.
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The dynamics of cyclin dependent kinase structure

Current Opinion in Cell Biology, 1996
In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition ...
openaire   +2 more sources