Results 291 to 300 of about 382,305 (392)

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

open access: yesJournal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi   +2 more
wiley   +1 more source

Exploring the Potential Anticancer Effects of Lobelia chinensis Lour in Liver Cancer via Multiomics Analysis

open access: yesMed Research, EarlyView.
The incidence and mortality of liver cancer remain consistently high worldwide, with China particularly affected. To identify potential therapeutic components and elucidate their mechanisms of action, this study performed a comprehensive multiomics analysis based on the active ingredients of LCL.
Zixuan Yang   +5 more
wiley   +1 more source

Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity

open access: green, 1999
Hikaru Nagahara   +5 more
openalex   +1 more source

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

open access: yesMolecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti   +4 more
wiley   +1 more source

Grape Seed Proanthocyanidins: A Potential Microbiome‐Targeted Intervention for Healthy Aging in Rats

open access: yesMolecular Nutrition &Food Research, EarlyView.
Grape seed proanthocyanidin extract (GSPE) promotes a healthier gut phenotype in aged rats. Aging alters gut microbiota composition, increases inflammation, and compromises intestinal barrier function. This study shows that short‐term GSPE treatment in aged rats partially restores microbial diversity toward a youthful profile, modulates mucus‐related ...
Marta Sierra‐Cruz   +10 more
wiley   +1 more source

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