Results 301 to 310 of about 382,305 (392)
ChemistryOpen, EarlyView.Tau protein aggregation and fibrillation have been examined in relationship to three metal ions in this study. The research was conducted to see the effects of Zn2+, Cu2+ and Fe3+ ions at different concentrations on tau′s conformation, cytotoxicity in SH‐SY5Y cells, and free thiol levels.
Mahzad Irandoust +6 more
wiley +1 more source
ChemistryOpen, EarlyView.Integrating synthesis, density functional theory studies, molecular docking, cytotoxicity, and ADMET predictions, this study identifies [CuII(salen)(H2O)2] (2) as a selective anticancer agent. Docking and in vitro assays highlight its favorable target interactions, selective anticancer activity, and reduced toxicity toward normal fibroblasts ...
Abdellatif A. Helaly +8 more
wiley +1 more source
Precision Medical Sciences, EarlyView.This study compares the diagnostic value of the anti‐p53 autoantibody as potential biomarkers for gastrointestinal cancer with enzyme‐linked immunosorbent assay technique. Abstract Gastrointestinal tract cancer is among the most common types of cancer and includes colorectal cancer (CRC) and gastric cancer (GC).
V. Hamidi Sofiani +7 more
wiley +1 more source
Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review
Phytotherapy Research, EarlyView.Phytoestrogen signal pathways targeted in ovarian cancer. ABSTRACT Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer‐related deaths in Western societies.
Ozgur Kutuk, Ayse Kaplan
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer ...
Sonali Khanal +9 more
wiley +1 more source
Insights Into Effects of Natural Bioactive Components on Inflammatory Diseases in Respiratory Tract
Phytotherapy Research, EarlyView.ABSTRACT The increasing prevalence of inflammatory diseases in the respiratory tract worldwide has raised concerns, and due to its high prevalence and poor prognosis, it remains a clinical focus and research hotspot. These inflammatory diseases include airway inflammation, asthma, bacterial antigens‐induced tonsil epithelial inflammation, chronic ...
Jincan Luo +4 more
wiley +1 more source
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, EarlyView.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
Mimicking breast cancer tissue—3D bioprinted models in accurate drug sensitivity tests
VIEW, EarlyView.Three‐dimensional (3D) bioprinted tumor models provide a novel method for studying drug sensitivity. This study compares drug response patterns of 3D bioprinted breast cancer models with xenografts and syngeneic tumors, showing that bioprinted models more accurately reflect the drug sensitivity and tissue heterogeneity of syngeneic tumor model.
Gábor Petővári +13 more
wiley +1 more source