Sodium Butyrate (NaB) and Sodium Propionate (NaP) Reduce Cyclin A2 Expression, Inducing Cell Cycle Arrest and Proliferation Inhibition of Different Breast Cancer Subtypes, Leading to Apoptosis [PDF]
BiomedicinesSodium butyrate (NaB) and sodium propionate (NaP) have recently garnered attention for their role in regulating inflammation and controlling signaling pathways of cell growth and apoptosis, potentially preventing cancer development.
José-Noel Ibrahim +7 more
doaj +3 more sources
Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas [PDF]
Analytical Cellular Pathology, 2018 We analysed the expression of cyclins A2, B1, D1, and E1 by immunohistochemistry and numerical aberrations in CCND1 gene by fluorescence in situ hybridization technique in 67 primary oral squamous cell carcinomas (OSCC). Cyclin A2 expression was observed
Luís Silva Monteiro +5 more
doaj +2 more sources
Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes. [PDF]
Int J Mol Med, 2017 Nitrogen-containing bisphosphonates (N-BPs) are the most widely used anti-resorptive agents in the treatment of bone-related diseases. N-BPs inhibit bone resorption by specifically targeting osteoclasts, bone-resorbing cells.
Lee RS +5 more
europepmc +3 more sources
Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]
, 2009 We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Atsushi Yoshiki +9 more
core +3 more sources
Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C [PDF]
Nature Communications, 2019 During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation.
Suyang Zhang +2 more
doaj +2 more sources
miRNA-31-5p Mediates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells via Targeting JAZF1 and Cyclin A2 [PDF]
Molecular Therapy: Nucleic Acids, 2019 Several lines of evidence highlight the important application of human spermatogonial stem cells (SSCs) in translational medicine. The fate decisions of SSCs are mainly mediated by genetic and epigenetic factors.
Hongyong Fu +6 more
doaj +2 more sources
Cucurbitacins mitigate vascular neointimal hyperplasia by suppressing cyclin A2 expression and inhibiting VSMC proliferation [PDF]
Animal Models and Experimental MedicineBackground Restenosis frequently occurs after percutaneous angioplasty in patients with vascular occlusion and seriously threatens their health. Substantial evidence has revealed that preventing vascular smooth muscle cell proliferation using a drug ...
Ruqiang Yuan +3 more
doaj +2 more sources
Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer. [PDF]
J Clin Invest, 2021 Guo Y +25 more
europepmc +3 more sources
Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress [PDF]
Nature Communications, 2018 Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to ...
Quentin Bayard +21 more
doaj +2 more sources
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1. [PDF]
Life Sci Alliance, 2021 Silva Cascales H +8 more
europepmc +3 more sources