Results 111 to 120 of about 43,048 (238)

Cyclin A2 as a regulator of DNA strand stability (1047.6)

The FASEB Journal, 2014
Cyclin A2 regulates replication origin firing during S‐phase. It binds to Cdk1 and Cdk2 to direct phosphorylation of proteins for DNA synthesis. The goals of this study were to determine the role of Cyclin A2 in the prevention of DNA double strand breaks (DSB). We deleted Cyclin A2 in mouse neural stem cells (NSC) using a cre/lox approach.
Patrick Gygli, Fay Catacutan, Hamza N. Gokozan, Kamalakannan Palanichamy, Theresa Schmidt, Jose Otero, Julie A. Stephens   +6 more
openaire   +1 more source

Toward molecular phenotyping of temporal lobe epilepsy by spatial omics

Epilepsia, EarlyView.
Abstract Objective In temporal lobe epilepsy (TLE), detection of the epileptogenic zone predicts a good surgical outcome. When submitted to 18F‐fluorodeoxyglucose positron emission tomography (PET), some patients display lateralized, focal hypometabolism in the temporal lobe (PET+), whereas others appear normometabolic (PET−).
Isabeau Vermeulen, Ronny Mohren, Micca Neusinger, Tobias A. Dancker, Michiel Vandenbosch, Jan Beckervordersandforth, Benjamin Balluff, Rianna P. Van der Hel, Olaf E. M. G. Schijns, Govert Hoogland, Kim Rijkers, Berta Cillero‐Pastor, ACE epilepsy surgery group, Gwendolyn de Bruyn, Albert Colon, Jim Dings, Marc Hendriks, Danny Hilkman, Christianne Hoeberigs, Jochem van der Pol, Lotte de Jong, Kim Rijkers, Sylvia Klinkenberg, Vivianne van Kranen–Mastenbroek, Jeske Nelissen, Pieter Kubben, Walter M. Palm, Rob P. W. Rouhl, Olaf Schijns, Ilse van Straaten, Simon Tousseyn, Marielle Vlooswijk, Louis Wagner, Dorien Weckhuysen   +33 more
wiley   +1 more source

Highly Complex Magnetic Structures Resulting From Hierarchical Phase Separation in AlCo(Cr)FeNi High Entropy Alloys [PDF]

arXiv, 2021
Magnetic high entropy alloys (HEAs) are a new category of high-performance magnetic materials, with multi-component concentrated compositions and complex multi-phase structures. Although there have been numerous reports of their interesting magnetic properties, there is very limited understanding about the interplay between their hierarchical multi ...
arxiv  

Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair [PDF]

, 2015
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of ...
Olson, Eric N., van Rooij, Eva
core   +1 more source

Cell Cycling Models of Carcinogenesis: A Complex Systems Analysis [PDF]

arXiv, 2004
A new approach to the modular, complex systems analysis of nonlinear dynamics in cell cycling network transformations involved in carcinogenesis is proposed. Carcinogenesis is a complex process that involves dynamically inter-connected biomolecules in the intercellular, membrane, cytosolic, nuclear and nucleolar compartments that form numerous inter ...
arxiv  

A2: Efficient Automated Attacker for Boosting Adversarial Training [PDF]

arXiv, 2022
Based on the significant improvement of model robustness by AT (Adversarial Training), various variants have been proposed to further boost the performance. Well-recognized methods have focused on different components of AT (e.g., designing loss functions and leveraging additional unlabeled data).
arxiv  

A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells [PDF]

, 2004
The evolution of the cell-cycle is known to be influenced by environmental conditions, including lack of extracellular oxygen (hypoxia). Notably, hypoxia appears to have different effects on normal and cancer cells.
Alarcon, T., Byrne, H. M., Maini, P. K.
core   +1 more source

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases

Orthopaedic Surgery, EarlyView.
Due to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Ruihao Xia, Hongjun Peng, Xishan Zhu, Wangdui Suolang, Steve T. L. Pambayi, Xiao Yang, Yi Zeng, Bin Shen   +7 more
wiley   +1 more source

Transection of the cervical sympathetic trunk inhibits the progression of pulmonary arterial hypertension via ERK-1/2 Signalling

Respiratory Research, 2019
Background Abnormal sympathetic hyperactivity has been shown to lead to pulmonary arterial hypertension (PAH) deterioration. The purpose of this study was to examine whether the transection of the cervical sympathetic trunk (TCST) can inhibit the ...
Yongpeng Zhao, Rui Xiang, Xin Peng, Qian Dong, Dan Li, Guiquan Yu, Lei Xiao, Shu Qin, Wei Huang   +8 more
doaj   +1 more source

Anisotropic Ejection from Active Asteroid P/2010 A2: An Implication of Impact Shattering on an Asteroid [PDF]

, 2017
We revisited a mass ejection phenomenon that occurred in asteroid P/2010 A2 in terms of the dynamical properties of the dust particles and large fragments. We constructed a model assuming anisotropic ejection within a solid cone-shaped jet and succeeded in reproducing the time-variant features in archival observational images over ~3 years from 2010 ...
arxiv   +1 more source