Results 121 to 130 of about 45,816 (242)

Supplementary Figure 3 from Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis [PDF]

, 2023
Lakshmi Gopinathan, Shawn Lu Wen Tan, V. C. Padmakumar, Vincenzo Coppola, Lino Tessarollo, Philipp Kaldis   +5 more
openalex   +2 more sources

CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point [PDF]

, 2013
Cell cycle progression, including genome duplication, is orchestrated by cyclin-dependent kinases (CDKs). CDK activation depends on phosphorylation of their T-loop by a CDK-activating kinase (CAK).
Bisteau, Xavier, Colleoni, Bianca, Coulonval, Katia, De Groote, Philippe, Declercq, Wim, Ecker, Karin, Hengst, Ludger, Paternot, Sabine, Roger, Pierre P   +8 more
core   +4 more sources

Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model

Allergy, EarlyView.
Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang, Jing Liu, Jing Ye, Li‐Ying Sun, Hsiao Hui Ong, Yang Peng, Bing‐Qi Lin, Jun‐Hao Tu, Ke‐Shuang Wang, Yi‐Shan Xiong, Qing Luo, Mark Thong, Yu Xu, De‐Yun Wang   +13 more
wiley   +1 more source

Transection of the cervical sympathetic trunk inhibits the progression of pulmonary arterial hypertension via ERK-1/2 Signalling

Respiratory Research, 2019
Background Abnormal sympathetic hyperactivity has been shown to lead to pulmonary arterial hypertension (PAH) deterioration. The purpose of this study was to examine whether the transection of the cervical sympathetic trunk (TCST) can inhibit the ...
Yongpeng Zhao, Rui Xiang, Xin Peng, Qian Dong, Dan Li, Guiquan Yu, Lei Xiao, Shu Qin, Wei Huang   +8 more
doaj   +1 more source

BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA

Developmental Biology, 2010
Developmental control of proliferation relies on tight regulation of protein expression. Although this has been well studied in early embryogenesis, how the cell cycle is regulated during organogenesis is not well understood. Bruno-Like RNA binding proteins bind to consensus sequences in the 3'UTR of specific mRNAs and repress protein translation, but ...
Horb, Lori Dawn, Horb, Marko E.
openaire   +2 more sources

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

Overexpression of Transferrin Receptor in Esophageal Squamous Cell Cancer Suggests Poor Prognosis and Potential Therapy

Cancer Science, EarlyView.
This study aimed to evaluate transferrin receptor (TfR) expression in human esophageal squamous cell cancer (ESCC) specimens and investigate the correlation between TfR overexpression and clinicopathological characteristics. Furthermore, we explored the potential of targeting iron metabolism pathways as a novel therapeutic strategy for ESCC.
Naoki Ikenaga, Tsuyoshi Takahashi, Koji Tanaka, Satoshi Serada, Minoru Fujimoto, Kota Momose, Kotaro Yamashita, Tomoki Makino, Takuro Saito, Kazuyoshi Yamamoto, Yukinori Kurokawa, Kiyokazu Nakajima, Tomomi Fujii, Eiichi Morii, Tetsuji Naka, Hidetoshi Eguchi, Yuichiro Doki   +16 more
wiley   +1 more source

The Impact of Heterotopic Spleen Regeneration on Tumor Growth. [PDF]

FASEB Bioadv
The present study evaluated the effect of spleen regeneration on tumor growth. Balb/c mice were divided into three groups: intact animals; animals that underwent splenectomy; animals that underwent splenectomy followed by autologous subcutaneous transplantation of spleen fragments.
Artemova D, Elchaninov A, Soboleva A, Arutyunyan I, Vishnyakova P, Gaydeek L, Fatkhudinov T, Sukhikh G.   +7 more
europepmc   +2 more sources

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF‐β/Smad Signalling Pathway

Cell Proliferation, EarlyView.
PHGDH promoted cardiomyocyte proliferation and myocardial regeneration via cell cycle and TGF‐β/Smad signalling pathways during cardiac repair. Moreover, PHGDH benefits cardiac repair and cardiomyocyte proliferation in mammalian mice following MI. ABSTRACT The mature mammalian heart has limited ability for self‐repair and regeneration.
Han Zhang, Li Zhang, Zehao Feng, Xing Li, Zhaohui Qiu, Xingyun Wang, Lingmei Qian   +6 more
wiley   +1 more source

A geometric method for model reduction of biochemical networks with polynomial rate functions

, 2015
Model reduction of biochemical networks relies on the knowledge of slow and fast variables. We provide a geometric method, based on the Newton polytope, to identify slow variables of a biochemical network with polynomial rate functions.
Fröhlich, H., Grigoriev, D., Radulescu, O., Samal, S., Weber, A.   +4 more
core   +2 more sources