Results 131 to 140 of about 19,762 (141)

Prognostic value of cyclin A2 and B1 expression in lung carcinoids

Pathology, 2019
Carcinoid classification in the lung is still based on morphological criteria. Although there are many studies investigating the role of Ki-67 proliferation index in the classification of lung neuroendocrine tumours, it is still not used in routine diagnostics.
Luka Brcic, Martin Heidinger, Anita Zenko Sever, Martin Zacharias, Marko Jakopovic, Melanie Fediuk, Alfred Maier, Franz Quehenberger, Sven Seiwerth, Helmut Popper   +9 more
openaire   +3 more sources

Characterization of the G₂-M function of cyclin A2

2020
Cell cycle is tightly regulated in eukaryotic cells through the activation of cyclin-dependent kinases (CDKs) by cyclins. Among the cyclin families, cyclin A (cyclin A2) is notable for its dual functions during the cell cycle. While cyclin A is a well-known S-phase promoting factor, its precise role in the G 2 -M transition still remains obscure.
openaire   +3 more sources

Cyclin A2 maintains colon homeostasis and is a prognostic factor in CRC.

2020
To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC), we generated mice deficient for cyclin A2 in colonic epithelial cells (CEC). Colons of those mice displayed architectural changes in the mucosa, and signs of inflammation as well as an increased proliferation of CEC associated with the appearance of low- and high ...
Guo, Yuchen, Gabola, Monica, Lattanzio, Rossano, Paul, Conception, Pinet, Valérie, Tang, Ruizhi, Turali, Hulya, Bremond, Julie, Longobardi, Ciro, Maurizy, Chloé, Da Costa, Quentin, Finetti, Pascal, Boissière-Michot, Florence, Rivière, Benjamin, Lemmers, Céline, Garnier, Séverine, Bertucci, François, Zlobec, Inti, Chebli, Karim, Tazi, Jamal, Azar, Rania, Blanchard, Jean-Marie, Sicinski, Peter, Mamessier, Emilie, Lemmers, Bénédicte, Hahne, Michael   +25 more
openaire   +2 more sources

331. INVESTIGATING THE ROLE OF CYCLIN A2 DURING OOCYTE MEIOSIS

Reproduction, Fertility and Development, 2010
Aneuploidy is often derived from chromosomal segregation errors in oocytes, leading to Down Syndrome and early embryo loss. Thus it is important to understand the molecular control of female meiosis. Cyclins and cyclin-dependent kinases (CDKs), particular those contributing to Maturation Promoting Factor (MPF, or CDK1) activity, play key roles in ...
Keith T. Jones, P. C. Jennings
openaire   +2 more sources

Cyclin A2 Plays a Critical Role in Proliferation of Lymphoid Progenitors

Blood, 2011
Abstract Abstract 914 Cell cycle regulators could be differentially used among self–renewing stem cells, rapidly expanding progenitor cells, and terminally differentiated cells those clonally replicate. Cyclin A is a regulatory subunit for cyclin dependent kinase (Cdk) 1 and Cdk2, and it drives S phase progression as well ...
Shinichi Mizuno, Koichi Akashi, Kentaro Kohno, Peter Sicinski, Tadafumi Iino, Hiromi Iwasaki   +5 more
openaire   +2 more sources

The functions of cyclin A2 in the G₂ DNA damage checkpoint

2019
Cell cycle checkpoints work as a double-edged sword. On the one hand, they facilitate DNA repair thus promoting the survival of normal tissues; on the other hand, they might reduce the effectiveness of many cancer treatments. Recent clinical trials on CHK1 and WEE1 inhibitors explored the potential of increasing the toxicity of chemo-and radio-therapy ...
openaire   +2 more sources

Cyclin A2

AfCS-Nature Molecule Pages, 2007
Randy Poon, Tsz Kan Fung
openaire   +1 more source

Cyclin A2

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

Cyclin-A2

2020
openaire   +1 more source

Role of Autophagy in Regulating Cyclin A2 Degradation

2017
Abdelhalim Loukil, Marion Peter
openaire   +1 more source