Results 141 to 150 of about 45,816 (242)
Role of Cyclin A2 In Aging Hippocampus And rRna Dynamics
The FASEB Journal, 2018 Background Novel functions of cyclin A2 ( CCNA2 ) have been demonstrated including DNA synthesis initiation and progression, DNA repair, and protein translation through RNA binding. Previously, we reported that loss of CCNA2
Michele Joana Alves +7 more
openaire +1 more source
Journal of Periodontal Research, EarlyView.A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed +6 more
wiley +1 more source
Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Annexin A2 receptor (AX2R) can mediate annexin A2 signalling and induce apoptosis in a variety of cells, but its role in neovascularization (NV) remains unclear.
Ting Guo +4 more
doaj +1 more source
Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver [PDF]
, 2014 Keap1 negatively controls the activity of transcription factor Nrf2. This Keap1/Nrf2 pathway plays a critical role in combating oxidative stress. We aimed at determining whether and how Keap1 modulates the cell cycle of replicating hepatocytes during ...
Dai, Guoli +5 more
core +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy +4 more
wiley +1 more source
Genomic and proteomic profiling of responses to toxic metals in human lung cells. [PDF]
, 2003 Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response ...
Andrew, Angeline S +7 more
core +2 more sources
Cyclin A2 Promotes DNA Repair and Neural Stem Cell Growth
The FASEB Journal, 2015 Mutations in DNA repair genes show peculiar defects in central nervous system morphogenesis characterized by dramatic cerebellar dysmorphia with relatively preserved forebrain development. Loss of the S‐phase cyclin CCNA2 parallels the phenotype of other DNA repair pathway genes.
Patrick Gygli +11 more
openaire +1 more source