Results 181 to 190 of about 45,816 (242)

The structural heterogeneity of AKT autoinhibition

Protein Science, Volume 35, Issue 1, January 2026.
Abstract AKT is key to controlling cell growth through the PI3K/AKT/mTOR pathway. In the cytosol, in the absence of stimulus, AKT is autoinhibited to prevent uncontrolled activation. Increased AKT activity contributes to tumor growth by phosphorylating numerous downstream targets.
Liang Xu, Meryem Eren, Jackson Weako, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +6 more
wiley   +1 more source

P36 | BIOLOGICAL ROLE OF DNA G-QUADRUPLEX DURING LIVER REGENERATION AFTER PARTIAL HEPATECTOMY

European Journal of Histochemistry
Guanine-rich DNA sequences can form four-stranded secondary structures known as G-quadruplexes (G4s). G4s exist in chromatin DNA and have linked G4 formation with the key processes from transcription and translation to genome instability1.
doaj   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Impact of a GABA‐Producing Lactococcus lactis on Microbiota and Mycobiota During CNS Inflammatory Demyelination

FASEB BioAdvances, Volume 8, Issue 1, January 2026.
GABA‐producing Lactococcus lactis protects against experimental autoimmune encephalomyelitis (EAE) in a mouse source‐dependent manner. The study focuses on the therapeutic potential of genetically engineered gamma‐aminobutyric acid (GABA)‐overproducing Lactococcus lactis (P8s‐GAD L. lactis) in the EAE model.
Kristina Hill, Alexandra LaFollette, Trevor O. Kirby, Soledad Negrete, Dani Babcock, Kari Felton, Hannah Kohl, Kavita Sharma, Andrea Castillo, Jean‐Baptiste Roullet, K. Michael Gibson, Javier Ochoa‐Repáraz   +11 more
wiley   +1 more source

Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica. [PDF]

, 2019
Neuromyelitis optica (NMO) is a refractory autoimmune inflammatory disease of the central nervous system without an effective cure. Autologous bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are considered to be promising therapeutic agents for this
Chang, Guoqiang, Ma, Li, Shi, Fu-Dong, Yan, Yaping, Yang, Chunsheng, Yang, Yang, Zhang, Guang-Xian   +6 more
core   +1 more source

Highly Coordinated Gene Regulation in Mouse Skeletal Muscle Regeneration [PDF]

, 2003
Mammalian skeletal muscles are capable of regeneration after injury. Quiescent satellite cells are activated to reenter the cell cycle and to differentiate for repair, recapitulating features of myogenesis during embryonic development.
Choi, Sangdun, Hart, Rebecca, Lee, Sun Young, Lin, Ling, Liu, Xuebin, Schageman, Jeoffrey J., Thurmond, Frederick A., Williams, R. Sanders, Yan, Zhen, Zhang, Mei   +9 more
core   +1 more source

Matrix Metalloproteinase Inhibition in Melanoma

Experimental Dermatology, Volume 35, Issue 1, January 2026.
ABSTRACT Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix (ECM) and are found to participate in all stages of tumour progression including modifying signalling pathways, regulating cytokines and promoting tumour growth, particularly by inducing angiogenesis and facilitating cancer spread.
Ellie Zhang, Varsha Thakur, Barbara Bedogni   +2 more
wiley   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Origin recognition complex 6 overexpression promotes growth of glioma cells

Cell Death and Disease
The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition complex 6) in glioma.
Wen-lei Yang, Wei-feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zhu   +5 more
doaj   +1 more source

CCDC97 is a Promising Predictor in Cancer Diagnosis: A Pan Cancer Analysis

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Background Coiled‐coil domain‐containing 97 (CCDC97) can bind to the splicing factor SF3B complex to participate significantly in pre‐mRNA splicing. However, there may be a risk of cancer development in the case of disrupted mechanism, necessitating further in‐depth investigation of the underlying mechanism.
Changye Yang, Ruirui Yang, Rundong Wang, Guo Ma, Lixin Hua, Maciej Wnuk   +5 more
wiley   +1 more source