Cocaine promotes primary human astrocyte proliferation via JNK-dependent up-regulation of cyclin A2. [PDF]
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Structural basis of T-loop-independent recognition and activation of CDKs by the CDK-activating kinase. [PDF]
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BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP. [PDF]
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High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants. [PDF]
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Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer. [PDF]
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BRPF1 inhibitor GSK6853 inhibits NSCLC cell proliferation via the JAK2/STAT3/CCNA2 axis to induce cell cycle arrest. [PDF]
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Knockout of protein arginine methyltransferase 1 inhibited cell growth and promoted cell migration in human bronchial epithelial cells. [PDF]
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Introduction: Small cell lung cancer (SCLC) is a special type of lung cancer sensitive to radiotherapy and chemotherapy but is prone to drug resistance and recurrence and has a very poor prognosis. This study aimed to explore the potential biomarkers and therapeutic targets for SCLC. Methods: After batch normalization of GSE40275, GSE1037, and GSE44447
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