Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation [PDF]
Science, 2016 Cyclin A2 activates the cyclin-dependent kinases Cdk1 and Cdk2 and is expressed at elevated levels from S phase until early mitosis. We found that mutant mice that cannot elevate cyclin A2 are chromosomally unstable and tumor-prone. Underlying the chromosomal instability is a failure to up-regulate the meiotic recombination 11 (Mre11 ...
Arun Kanakkanthara +16 more
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Cyclin A2, a novel regulator of EMT [PDF]
Cellular and Molecular Life Sciences, 2014 Our previous work showed that Cyclin A2 deficiency promotes cell invasion in fibroblasts. Given that the majority of cancers emerge from epithelia, we explored novel functions for Cyclin A2 by depleting it in normal mammary epithelial cells. This caused an epithelial to mesenchymal transition (EMT) associated with loss of cell-to-cell contacts ...
Hon S. Leong +9 more
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Cyclin A2, Rho GTPases and EMT [PDF]
Small GTPases, 2012 Cell cycle regulators, such as cyclins, are often upregulated in many proliferative disorders, and Cyclin A2 is generally considered as a marker of aggressive cancers. Our recent work, which revealed decreased expression of Cyclin A2 upon metastasis of colorectal cancer, suggests a more complicated situation.
Bendris, Nawal +3 more
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Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis [PDF]
Cancer Research, 2014 Abstract Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed in cancer where it may impact cell proliferation.
Lakshmi Gopinathan +5 more
europepmc +5 more sources
The Predictive Competing Endogenous RNA Regulatory Networks and Potential Prognostic and Immunological Roles of Cyclin A2 in Pan-Cancer Analysis [PDF]
Front Mol Biosci, 2022 Shengyong Chen +5 more
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NUSAP1 Accelerates Osteosarcoma Cell Proliferation and Cell Cycle Progression via Upregulating CDC20 and Cyclin A2 [PDF]
Onco Targets Ther, 2021 Haoran Wang +4 more
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Developmental Biology, 2000 Progression through the mammalian cell cycle is regulated by the sequential activation and inactivation of the cyclin-dependent kinases. In adult cells, cyclin A2-dependent kinases are required for entry into S and M phases, completion of S phase, and centrosome duplication.
Nicola Winston +7 more
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ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability [PDF]
Int J Mol Sci, 2019 Zhihong Chen +6 more
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Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2 [PDF]
Biochemical and Biophysical Research Communications, 2008 The distinct expression patterns of the two A-type cyclins during spermatogenesis and the absolute requirement for cyclin A1 in this biological process in vivo suggest that they may confer distinct biochemical properties to their CDK partners. We therefore compared human cyclin A1- and cyclin A2-containing CDK complexes in vitro by determining kinetic ...
Ayesha R. Joshi +3 more
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A novel function for Cyclin A2: Control of cell invasion via RhoA signaling [PDF]
Journal of Cell Biology, 2012 Cyclin A2 plays a key role in cell cycle regulation. It is essential in embryonic cells and in the hematopoietic lineage yet dispensable in fibroblasts. In this paper, we demonstrate that Cyclin A2–depleted cells display a cortical distribution of actin filaments and increased migration.
Nikola Arsic +9 more
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