Results 41 to 50 of about 45,816 (242)

Transcriptional Regulation of Cyclin A2 by RASSF1A through the Enhanced Binding of p120E4F to the Cyclin A2 Promoter [PDF]

Cancer Research, 2005
Abstract Recent advances in the study of RASSF1A, the candidate tumor suppressor gene, indicate a possible role of RASSF1A in cell cycle regulation; however, very little is known regarding molecular mechanisms underlying this control. Using small interfering RNA to knockdown endogenous RASSF1A in the breast tumor cell line HB2 and in the
Jalal, Ahmed-Choudhury, Angelo, Agathanggelou, Sarah L, Fenton, Christopher, Ricketts, Geoffrey J, Clark, Eamonn R, Maher, Farida, Latif   +6 more
openaire   +2 more sources

Cyclin A2 Mediates Cardiomyocyte Mitosis in the Postmitotic Myocardium [PDF]

Journal of Biological Chemistry, 2004
Cell cycle withdrawal limits proliferation of adult mammalian cardiomyocytes. Therefore, the concept of stimulating myocyte mitotic divisions has dramatic implications for cardiomyocyte regeneration and hence, cardiovascular disease. Previous reports describing manipulation of cell cycle proteins have not shown induction of cardiomyocyte mitosis after ...
Wolgemuth, DJ, Dashoush, NH, Wu, EX, Wan, X, Zhang, L, Tang, H, Chaudhry, HW   +6 more
openaire   +4 more sources

Cyclin A2 Is Required for Sister Chromatid Segregation, But Not Separase Control, in Mouse Oocyte Meiosis

Cell Reports, 2012
In meiosis, two specialized cell divisions allow the separation of paired chromosomes first, then of sister chromatids. Separase removes the cohesin complex holding sister chromatids together in a stepwise manner from chromosome arms in meiosis I, then ...
Sandra A. Touati, Damien Cladière, Lisa M. Lister, Ioanna Leontiou, Jean-Philippe Chambon, Ahmed Rattani, Franziska Böttger, Olaf Stemmann, Kim Nasmyth, Mary Herbert, Katja Wassmann   +10 more
doaj   +1 more source

Mammaglobin 1 mediates progression of trastuzumab‐resistant breast cancer cells through regulation of cyclins and NF‐κB

FEBS Open Bio, 2022
Overexpression of human epidermal growth factor receptor 2 (HER2) in various cancers is correlated with poor patient survival. Trastuzumab, a recombinant humanized monoclonal antibody against HER2, has been considered to be a first‐line therapy for HER2 ...
Ratih Kusumastuti, Yuji Kumagai, Seiichiro Ishihara, Atsushi Enomoto, Takashi Murakami, Motoaki Yasuda, Hisashi Haga   +6 more
doaj   +1 more source

Cyclin A2 Regulates Nuclear-Envelope Breakdown and the Nuclear Accumulation of Cyclin B1 [PDF]

Current Biology, 2007
Mitosis is thought to be triggered by the activation of Cdk-cyclin complexes. Here we have used RNA interference (RNAi) to assess the roles of three mitotic cyclins, cyclins A2, B1, and B2, in the regulation of centrosome separation and nuclear-envelope breakdown (NEB) in HeLa cells.
Gong, Delquin, Pomerening, Joseph R., Myers, Jason W., Gustavsson, Christer, Jones, Joshua T., Hahn, Angela T., Meyer, Tobias, Ferrell, James E.   +7 more
openaire   +2 more sources

LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression. [PDF]

PLoS ONE, 2014
Cell cycle transitions are governed by the timely expression of cyclins, the activating subunits of Cyclin-dependent kinases (Cdks), which are responsible for the inactivation of the pocket proteins.
Frank Eckerdt, Mathew Perez-Neut, Oscar R Colamonici   +2 more
doaj   +1 more source

Cyclin A2: At the crossroads of cell cycle and cell invasion. [PDF]

World J Biol Chem, 2015
Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However, whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed, recent observations show that a small fraction of cyclin A2 ...
Loukil A, Cheung CT, Bendris N, Lemmers B, Peter M, Blanchard JM.   +5 more
europepmc   +3 more sources

Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis [PDF]

, 2015
Genome-wide association studies (GWAS) hold tremendous promise to improve our understanding of human biology. Recent GWAS have revealed over 75 loci associated with erythroid traits, including the 4q27 locus that is associated with red blood cell size ...
An, Flygare, Furuno, Harst, Iolascon, Ji, Kadauke, Kalaszczynska, Kellis, Kim, Lander, Liljeholm, Murdock, Novershtern, Paul, Sankaran, Sankaran, Sankaran, Sankaran, Thom, Traxler, Ulirsch, Weiss, Wu, Wu, Zhang   +25 more
core   +1 more source

Cyclin A2 mutagenesis analysis: a new insight into CDK activation and cellular localization requirements.

PLoS ONE, 2011
Cyclin A2 is essential at two critical points in the somatic cell cycle: during S phase, when it activates CDK2, and during the G2 to M transition when it activates CDK1.
Nawal Bendris, Bénédicte Lemmers, Jean-Marie Blanchard, Nikola Arsic   +3 more
doaj   +1 more source

Dynamic epitope expression from static cytometry data: principles and reproducibility. [PDF]

PLoS ONE, 2012
An imprecise quantitative sense for the oscillating levels of proteins and their modifications, interactions, and translocations as a function of the cell cycle is fundamentally important for a cartoon/narrative understanding for how the cell cycle works.
James W Jacobberger, Jayant Avva, Sree N Sreenath, Michael C Weis, Tammy Stefan   +4 more
doaj   +1 more source