Bright spots in the darkness of cancer: A review of starfishes-derived compounds and their anti-tumor action [PDF]
, 2019 The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable.
Arizza V. +4 more
core +1 more source
Cyclin A2 modulates EMT via β-catenin and phospholipase C pathways [PDF]
Carcinogenesis, 2015 We have previously demonstrated that Cyclin A2 is involved in cytoskeletal dynamics, epithelial-mesenchymal transition (EMT) and metastasis. This phenotype was potentiated by activated oncogenic H-Ras. However, the mechanisms governing EMT in these cells have not yet been elucidated. Here, we dissected the pathways that are responsible for EMT in cells
Cheung, Caroline +7 more
openaire +3 more sources
Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]
, 2014 We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura +10 more
core +1 more source
Biomedicines, 2022 Precise regulation of DNA replication complex assembly requires cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK) activities to activate the replicative helicase complex and initiate DNA replication. Chemical probes have been essential in the
Tekle Pauzaite +8 more
doaj +1 more source
Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells [PDF]
, 2017 Previous results link the mitochondrial potassium channel Kv1.3 (mitoKv1.3) to the regulation of apoptosis. By synthesizing new, mitochondria-targeted derivatives (PAPTP and PCARBTP) of PAP-1, a specific membrane-permeant Kv1.3 inhibitor, we have ...
Amigorena +48 more
core +2 more sources
Posttranscriptional Regulation of Cyclin A1 and Cyclin A2 During Mouse Oocyte Meiotic Maturation and Preimplantation Development1 [PDF]
Biology of Reproduction, 2001 Daiichiro Fuchimoto +4 more
openalex +2 more sources
PLoS Pathogens, 2014 Entry into mitosis is accompanied by dramatic changes in cellular architecture, metabolism and gene expression. Many viruses have evolved cell cycle arrest strategies to prevent mitotic entry, presumably to ensure sustained, uninterrupted viral ...
Martin Eifler +11 more
doaj +1 more source
UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis
Molecular Biology of the Cell, 2012 Ubiquitin-like, containing PHD and RING finger domains 1 (uhrf1) is regulated at the transcriptional level during the cell cycle and in developing zebrafish embryos. We identify phosphorylation as a novel means of regulating UHRF1 and demonstrate that Uhrf1 phosphorylation is required for gastrulation in zebrafish.
Chu, Jaime +10 more
openaire +2 more sources
A functional role of LEFTY during progesterone therapy for endometrial carcinoma
Cell Communication and Signaling, 2017 Background The left-right determination factor (LEFTY) is a novel member of the TGF-β/Smad2 pathway and belongs to the premenstrual/menstrual repertoire in human endometrium, but little is known about its functional role in endometrial carcinomas (Em Cas)
Wu Fei +8 more
doaj +1 more source
Therapeutic target discovery using Boolean network attractors: avoiding pathological phenotypes [PDF]
, 2014 Target identification, one of the steps of drug discovery, aims at identifying biomolecules whose function should be therapeutically altered in order to cure the considered pathology.
Boissel, Jean-Pierre, Poret, Arnaud
core +4 more sources