Results 81 to 90 of about 45,816 (242)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Relationship between the Release of Interleukin 12 and the Expression of PCNA, Cyclin A2, and CDK2 in Lung Cancer Cells

Journal of Oncological Sciences
Objective: Mesenchymal stem cell (MSC)-based IL-12 release therapy may be less toxic than direct administration of IL-2. We investigated the release of interleukin (IL)-12 in MSCs and A549 cocultures and identified the time points at which IL-12 is ...
Meliha Burcu IRMAK YAZICIOĞLU, Seval TURNA   +1 more
doaj   +1 more source

Comparison of Perron and Floquet eigenvalues in age structured cell division cycle models [PDF]

, 2008
We study the growth rate of a cell population that follows an age-structured PDE with time-periodic coefficients. Our motivation comes from the comparison between experimental tumor growth curves in mice endowed with intact or disrupted circadian clocks,
Arino, Arino, Bekkal Brikci, Bekkal Brikci, Clairambault, Clairambault, Doumic, J. Clairambault, Levi, Levi, S. Gaubert, Th. Lepoutre, Tyson   +12 more
core   +6 more sources

Differential phosphorylation patterns between the Cyclin-A2/CDK2 complex and their monomers [PDF]

Protein Expression and Purification, 2009
The Cyclin-A2/CDK2 is a protein heterodimer with kinase activity that plays a key role in centrosome duplication and meiotic cell division. To check the suitability of the insect cells for the production and characterization of phosphorylated mammalian proteins, both proteins were expressed individually or as a complex using the baculovirus expression ...
Casado-Vela, Juan, Martínez-Torrecuadrada, Jorge Luis, Casal, J. Ignacio   +2 more
openaire   +3 more sources

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair [PDF]

, 2018
Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning - the E3/E4 ubiquitin ligase, UBE4A.
Baranes Bachar, Keren, Huertas Sánchez, Pablo, Levy Barda, Adva, Oehler, Judith, Soria Bretones, Isabel   +4 more
core   +1 more source

Cyclin A2 Induces Cardiac Regeneration After Myocardial Infarction and Prevents Heart Failure [PDF]

Circulation Research, 2007
Mammalian myocardial infarction is typically followed by scar formation with eventual ventricular dilation and heart failure. Here we present a novel model system in which mice constitutively expressing cyclin A2 in the myocardium elicit a regenerative response after infarction and exhibit significantly limited ventricular dilation with sustained and ...
Dashoush, NH, Kara, RJ, Costa, KD, Naka, Y, Wu, EX, Wolgemuth, DJ, Chaudhry, HW, Cheng, RK, Asai, T, Tang, H   +9 more
openaire   +4 more sources

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Cyclin A2 regulates symmetrical mitotic spindle formation and centrosome amplification in human colon cancer cells. [PDF]

Am J Transl Res, 2018
Li JA, Liu BC, Song Y, Chen X.
europepmc   +2 more sources

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source