Results 121 to 130 of about 592,070 (354)
Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
Neural Development, 2009 Background Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina.
Choi Yoon +3 more
doaj +1 more source
The cycline subalgebra of a Kumjian-Pask algebra [PDF]
Proc. Amer. Math. Soc. 145 (2017), no. 5, 1969-1980, 2016 Let $\Lambda$ be a row-finite higher-rank graph with no sources. We identify a maximal commutative subalgebra $\mathcal{M}$ inside the Kumjian-Pask algebra ${\rm KP}_R(\Lambda)$. We also prove a generalized Cuntz-Krieger uniqueness theorem for Kumjian-Pask algebras which says that a representation of ${\rm KP}_R(\Lambda)$ is injective if and only if it
arxiv
Prediction of repurposed drugs for treating lung injury in COVID-19 [PDF]
arXiv, 2020 Coronavirus disease (COVID-19) is an infectious disease discovered in 2019 and currently in outbreak across the world. Lung injury with severe respiratory failure is the leading cause of death in COVID-19, brought by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
arxiv
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes. [PDF]
, 2017 Nitrogen-containing bisphosphonates (N-BPs) are the most widely used anti-resorptive agents in the treatment of bone-related diseases. N-BPs inhibit bone resorption by specifically targeting osteoclasts, bone-resorbing cells.
Kang, Mo K +5 more
core +1 more source
An Analysis for IDH‐Mutant Grade 4 Astrocytoma Based on WHO CNS 5: Implication of Clinical Practice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose There is ongoing debate regarding the therapeutic approach and prognosis for IDH‐mutant grade 4 astrocytoma, a newly defined subtype of diffuse glioma in the 2021 WHO classification system for central nervous system tumors (WHO CNS 5). The aim of this study was to explore the clinical outcome and prognosticators for newly diagnosed IDH‐
Xianxin Qiu +13 more
wiley +1 more source
Periodic higher rank graphs revisited [PDF]
arXiv, 2014 Let $P$ be a finitely generated cancellative abelian monoid. A $P$-graph $\Lambda$ is a natural generalization of a higher rank graph. A pullback of $\Lambda$ is constructed by pulling it back over a given monoid morphism to $P$, while a pushout of $\Lambda$ is obtained by modding out its periodicity $\Per\Lambda$, which is deduced from a natural ...
arxiv
Advanced Biology, EarlyView.The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua +5 more
wiley +1 more source
Indian Journal of Medical and Paediatric Oncology, 2019 The cyclin D-cyclin-dependent kinase (CDK) 4/6 pathway controls the cell cycle machinery by regulating the G1-to-S-phase transition. Dysregulation of this pathway, resulting in increased cellular proliferation, is frequently observed in a variety of ...
Tamojit Chaudhuri +8 more
doaj +1 more source
The Italian bondage and reinforcement numbers of digraphs [PDF]
arXiv, 2020 An \textit{Italian dominating function} on a digraph $D$ with vertex set $V(D)$ is defined as a function $f : V(D) \rightarrow \{0, 1, 2\}$ such that every vertex $v \in V(D)$ with $f(v) = 0$ has at least two in-neighbors assigned $1$ under $f$ or one in-neighbor $w$ with $f(w) = 2$.
arxiv