Results 241 to 250 of about 306,671 (274)

Ras signals principally via Erk in G1 but cooperates with PI3K/Akt for Cyclin D induction and S-phase entry. [PDF]

Cell Cycle, 2019
Vasjari L, Bresan S, Biskup C, Pai G, Rubio I.   +4 more
europepmc   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

International Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin, Venugopalareddy Mekala, Jianrong Li, Xiang Wang, Muhammad Aminu, Jia Wu, Jianjun Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng   +9 more
wiley   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Dramatic response to cyclin D-dependent kinase 4/6 inhibitor in refractory poorly differentiated neuroendocrine carcinoma of the breast. [PDF]

Proc (Bayl Univ Med Cent), 2018
Shanks A, Choi J, Karur V.
europepmc   +1 more source

Pyrido[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases

, 2000
Mark R. Barvian, Diane H. Boschelli, Jennifer Cossrow, Ellen M. Dobrusin, Ali Fattaey, Alex Fritsch, David W. Fry, Patricia J. Harvey, Paul R. Keller, Michelle D. Garrett, Frances La, Wilbur R. Leopold, Dennis J. McNamara, Maire Quin, Susanne Trumpp-Kallmeyer, Peter L. Toogood, Zhipei Wu, Erli Zhang   +17 more
openalex   +1 more source

Case Report and Literature Review: Intrathyroid Thymic Carcinoma

Journal of Clinical Ultrasound, EarlyView.
This case report highlights the challenges in diagnosing intrathyroid thymic carcinoma (ITTC), a rare thyroid tumor, and underscores the importance of postoperative pathology for confirmation. The study emphasizes the good prognosis of ITTC with appropriate surgical management.
Jia‐Yue Sun, Ji Qi, Yi‐Lin Hou, Yun‐Fei Zhang   +3 more
wiley   +1 more source

LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway. [PDF]

Nat Commun, 2018
Gao A, Sun T, Ma G, Cao J, Hu Q, Chen L, Wang Y, Wang Q, Sun J, Wu R, Wu Q, Zhou J, Liu L, Hu J, Dong JT, Zhu Z.   +15 more
europepmc   +1 more source

The effect of hydrogen peroxide on the cyclin D expression in fiborblasts

, 2001
C.Martı́nez Muñoz, Jan A. Post, Arie J. Verkleij, C. Theo Verrips, J. Boonstra   +4 more
openalex   +2 more sources

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. [PDF]

Nature, 2018
Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira NT, Tan Y, Ci Y, Wu F, Dai X, Guo J, Huang YH, Fan C, Ren S, Sun Y, Freeman GJ, Sicinski P, Wei W.   +17 more
europepmc   +1 more source