Results 151 to 160 of about 2,643,362 (304)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Cycling UK: Marlon Moncrieffe on the Black British cycling community
, 2022 Dr Marlon Moncrieffe, an academic and former elite level racing cyclist, is the author of Black Champions in Cycling.
Moncrieffe, Marlon; id_orcid
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Cycles in Graphs with Prescribed Stability Number and Connectivity
Journal of Combinatorial Theory, Series B, 1994 The paper provides verification of a conjecture of Amar, Fournier, Häggkvist and Thomassen that the vertices of a \(k\)-connected graph with stability number \(\alpha\) can be covered by \(\lceil \alpha/k \rceil\) cycles.
openaire +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Reproducibility of a Laboratory Based 1-km Wattbike Cycling Time Trial in Competitive Cyclists
, 2014 The purpose of this study was to evaluate the reliability of a 1-km cycling time trial using a Wattbike cycling ergometer in competitive cyclists. Ten competitive male cyclists (mean ᠓D; 63.9 ᠵ.1 mL竧-1筩n-1) performed a VO2max test and a familiarization ...
Bellinger, Phil, Minahan, Clare
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Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Advanced ScienceMetal–organic frameworks (MOFs) have played a crucial role in recent advancements in developing lithium‐based battery electrolytes, electrodes, and separators.
Anthony U. Mu, Guorui Cai, Zheng Chen
doaj +1 more source