Results 131 to 140 of about 2,643,362 (304)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Stability in Bondy's theorem on paths and cycles
Journal of Combinatorial Theory, Series BIn this paper, we study the stability result of a well-known theorem of Bondy. We prove that for any 2-connected non-hamiltonian graph, if every vertex except for at most one vertex has degree at least $k$, then it contains a cycle of length at least $2k+2$ except for some special families of graphs.
Bo Ning, Long-Tu Yuan
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Overview: Cycling Scotland was established in 2003 as a national charity to represent cycling interests and to increase levels of cycling. Our vision is of a sustainable, inclusive and healthy Scotland where anyone, anywhere, can enjoy all the ...
Cycling Scotland
core
Momentum integration: the syntax of cycling [PDF]
, 2015 Cycling has long been known to have significant physical and mental health benefits for its participants. It has the potential to significantly reduce the carbon footprint of a city, increase personal mobility, improve transportation equality, improve ...
Dalton, Nicholas, Dalton, Nick
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Understanding urban cycling behaviours in space and time [PDF]
The aim of this research thesis was to understand how the urban built environment interacts with utility cycling behaviours in space and time. Using mixed methods entrenched in the philosophy of pragmatism, the research contributed to an as yet under ...
Yeboah, Godwin
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
BatteriesSodium (Na) metal anodes suffer from poor processability, severe volume fluctuation, unstable interfacial chemistry, and uncontrolled dendrite growth during cycling, which significantly hinder their practical application.
Bingqian Zhang +8 more
doaj +1 more source