Results 101 to 110 of about 121,287 (309)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Electrophilic Cyclization of 1,6-Enynes
, 2011 The NIS-mediated iodocyclization of 1,6-enynes is described. While 1,6-enynes with a cation-stabilizing substituent at C2 position undergo 6-exo cyclization in poor yields, 1,6-enynes with donor substituents at C1 position favor the 5-exo mode of ...
Harschneck, T.;Kirsch, S. F.;Wegener, M.
core +1 more source
Functionalized 4-Hydroxy Coumarins: Novel Synthesis, Crystal Structure and DFT Calculations
Molecules, 2011 A novel short-step methodology for the synthesis in good yields of functionalized coumarins has been developed starting from an activated precursor, the N-hydroxysuccinimide ester of O-acetylsalicylic acid.
Olga Igglessi-Markopoulou +7 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
, 2013 Synthesis of Functionalized Oxazoles Via Silver Catalyzed Cyclization of Propargylamides and ...
易如霞, 吴凡, 万伯顺, 呼延成
core
Emergence of terpene cyclization in Artemisia annua [PDF]
, 2015 The emergence of terpene cyclization was critical to the evolutionary expansion of chemical diversity yet remains unexplored. Here we report the first discovery of an epistatic network of residues that controls the onset of terpene cyclization in ...
Laurendon, Caroline +8 more
core +1 more source
Recent Advances in the Synthesis of Thiophene Derivatives by Cyclization of Functionalized Alkynes
Molecules, 2014 This review is intended to highlight some recent and particularly interesting examples of the synthesis of thiophene derivatives by heterocyclization of readily available S-containing alkyne substrates.
Raffaella Mancuso, Bartolo Gabriele
doaj +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
An Oxidative Prins Cyclization Methodology
, 2016 An Oxidative Prins Cyclization ...
Patrick S. Mariano (1909225) +1 more
core +1 more source
Organic Letters, 2016 An expedient procedure for catalytic oxidative azo-ene cyclization of allylic and homoallylic 1,2-hydrazinedicarboxylates is reported. The reaction produced a wide range of cyclic carbamate derivatives featuring an appended alkene fragment ready for further functionalization.
Nolwenn Derrien +3 more
openaire +4 more sources