Results 221 to 230 of about 797,239 (340)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Photoredox Iron-Catalyzed Decarboxylative Radical Cyclization for the Synthesis of Oxindoles and Chroman-4-ones. [PDF]
Han S+5 more
europepmc +1 more source
THE RESPONSE OF SUGARCANE TO FERTILIZERS I. THE ARECIBO CYCLE, 1944-1950
George Samuels, Pablo Landrau
openalex +2 more sources
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Advancing the synthesis of trimethylene carbonate: a high-yield green synthesis route. [PDF]
Ning Z, Li Y, Dai L, Liu D, Du W.
europepmc +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source
Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin. [PDF]
Ishimoto N+12 more
europepmc +1 more source
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald+18 more
wiley +1 more source
Fused Nitrogen Bridgehead N,O-Acetals as Versatile Scaffolds: Synthetic Strategies, Mechanism and Applications. [PDF]
Kouvelas AD, Kallitsakis MG, Lykakis IN.
europepmc +1 more source