Results 231 to 240 of about 831,285 (343)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Chemoselective sulfonyl fluoride exchange (SuFEx)-induced macrocyclization of tyrosine-containing peptides in aqueous media. [PDF]

Chem Sci
Seyrani H, Heidarzadeh Vazifehkhorani H, Outlaw VK.   +2 more
europepmc   +1 more source

Life cycle inventory analysis of medical textiles and their role in prevention of nosocomial infections

, 2009
Celia S. Ponder
openalex   +1 more source

Temporal power of a cycling sprinter: experiments and effective time theory

Christophe Clanet, Iris Sachet, Sylvain Dorel, C. M. S. Cohen, Baptiste Morel, Maximilien Bowen, Pierre Samozino, Emmanuel Brunet   +7 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Asymmetric Synthesis of Quaternary Hydantoins via a Palladium-Catalyzed Aza-Heck Cyclization. [PDF]

J Am Chem Soc
Meck EA, Omer HM, Edwards MJ, Idowu TD, Murray ML, Korch KM, Watson DA.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Vinigrol Tricyclic Scaffold Biosynthesis Employs an Atypical Terpene Cyclase and a Multipotent Cyclization Cascade. [PDF]

J Am Chem Soc
Tsukada K, Sato F, Matsuyama T, Matsuda R, Ozaki T, Morishita Y, Furumura S, Homma Y, Sekiya H, Sugawara A, Kubota M, Mitsuhashi T, Yasuno Y, Shinada T, Nagata R, Kuzuyama T, Taniguchi T, Fujita M, Uchiyama M, Asai T.   +19 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Efficient one-pot quinoline derivative synthesis from acetophenone and allyl alcohols. [PDF]

RSC Adv
Zeng F, Xu Y, Fang J, Xu H, Cai Y, Hong Y, Gao J, Zeng Q, Su X.   +8 more
europepmc   +1 more source