Results 251 to 260 of about 157,130 (323)

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

open access: yesChemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow   +2 more
wiley   +1 more source

Rh‐Catalyzed [2 + 2 + 2] Cycloaddition of Linked Bis(Diynes) Ar‐C≡C‐C≡C‐(CH2)3‐C≡C‐C≡C‐Ar With Quinones: Synthesis and Photophysical Properties of Bis(Arylethynyl)‐Naphthoquinones and Anthraquinones

open access: yesChemistry – A European Journal, EarlyView.
We report the synthesis bis(arylethynyl)naphtho‐ and anthraquinones via Rh(I)‐catalyzed [2 + 2 + 2] cycloaddition reactions. The substrate scope of both quinones and linked bis‐diynes was explored. Microwave irradiation remarkably enhanced yields.
Luana A. Machado   +16 more
wiley   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

open access: yesChemistry – A European Journal, EarlyView.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret   +9 more
wiley   +1 more source

Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis

open access: yesChemistry – A European Journal, EarlyView.
Mechanochemistry offers a sustainable, solvent‐free alternative to traditional synthesis, often enhanced by additives in a process known as additive‐assisted grinding. This review discusses how various additives, including liquids, ionic solids, and advanced materials like ionic liquids and piezoelectric compounds, improve reaction efficiency ...
Johanna Breinsperger   +3 more
wiley   +1 more source

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