Molecules, 2023 The synthesis of dicyclic spiropyridazine oxoindole derivatives by using [3+3]-cycloaddition of N-unsubstituted isatin N,N′-cyclic azomethine imine 1,3-dipoles was reported.
Guosheng Yang +9 more
doaj +1 more source
Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro [PDF]
, 2014 Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s).
Crot, Stéphanie +3 more
core +1 more source
Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates
Molecules, 2016 A novel series of diethyl {4-[(5-substituted-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates designed as analogues of amonafide was synthesized.
Iwona E. Głowacka +6 more
doaj +1 more source
Molecules, 2022 4-Acyl-1H-pyrrole-2,3-diones fused at [e]-side with a heterocyclic moiety are suitable platforms for the development of a hetero-Diels–Alder-reaction-based, diversity-oriented approaches to series of skeletally diverse heterocycles.
Ekaterina E. Khramtsova +3 more
doaj +1 more source
[2 + 2]-Cycloaddition of a stabilised vinyl cation with cyclopentadiene; X-ray crystal structure of the 2 : 1 addition product [PDF]
, 1981 Lewis acid-catalysed reaction of 1,1-dimethyl-3-phenylprop-2-ynyl chloride with cyclopentadiene yields a 2 : 1 addition product via[2 + 2]-cycloaddition of an intermediate allenyl ...
Kaliba, Claus +2 more
core +1 more source
Quantum-chemistry-aided identification, synthesis and experimental validation of model systems for conformationally controlled reaction studies: Separation of the conformers of 2,3-dibromobuta-1,3-diene in the gas phase [PDF]
, 2020 The Diels-Alder cycloaddition, in which a diene reacts with a dienophile to form a cyclic compound, counts among the most important tools in organic synthesis. Achieving a precise understanding of its mechanistic details on the quantum level requires new experimental and theoretical methods.
arxiv +1 more source
Synthetic Studies on Erythromycin Derivatives: Reactivity of the C12-21 Alkene
Molecules, 2006 The reactivity of the C12-21 alkene of some erythromycin A derivatives was studied. This double bond was easily oxidized to the corresponding epoxide with excellent stereoselectivity. A single crystal X-ray structure showed that the epoxide moiety was on
Wei-Min Chen
doaj +1 more source
Donor-Acceptor Substituted Benzo-, Naphtho- and Phenanthro-Fused Norbornadienes
Molecules, 2020 The photochromic norbornadiene/quadricyclane (NBD/QC) couple has found interest as a molecular solar thermal energy (MOST) system for storage of solar energy.
Mads Mansø +4 more
doaj +1 more source
Azomethine Ylides—Versatile Synthons for Pyrrolidinyl-Heterocyclic Compounds
Molecules, 2023 Azomethine ylides are nitrogen-based three-atom components commonly used in [3+2]-cycloaddition reactions with various unsaturated 2π-electron components.
Siva S. Panda +3 more
doaj +1 more source
Synthesis of pyrrolizines by intramolecular capture of 1,4-dipolar intermediates in reactions of enamines with dimethyl acetylenedicarboxylate [PDF]
, 1981 Solvent polarity and reaction temperature strongly influence the reactions of dimethyl acetylenedicar-boxylate (DMAD) with 1-pyrrolidinyl enamines of acyclic and cyclic ketones. Whereas DMAD and 1-[1-phenyl-2-(phenylthio)ethenyl]pyrrolidine (3) give only
Harkema, S. +5 more
core +3 more sources