Developing new reaction to synthesize challenging eight-membered carbocycles is a research frontier of organic synthesis. Reported here is the development of the first Rh-catalyzed [5 + 1 + 2] cycloaddition of yne-3-acyloxy-1,4-enyne (Yne-ACEs, short as ...
Hong-Xi, Bai +6 more
core +1 more source
Stereoselective Synthesis of Densely Substituted Pyrrolidines via a [3 + 2] Cycloaddition Reaction between Chiral N-tert-Butanesulfinylazadienes and Azomethine Ylides. [PDF]
Blanco-López E +3 more
europepmc +1 more source
Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+2] Cycloaddition Reaction: An MEDT Study of the Mechanism and Selectivity. [PDF]
Alshahrani S +7 more
europepmc +1 more source
A Chiral Saddle‐Shaped Nanographene With Two Heptagon‐Embedded [4]Helicenes
We present a novel synthetic strategy toward a chiral saddle‐shaped nanographene (cSNG) via a two‐step oxidation of a prochiral anthracene precursor. The Scholl‐type oxidation first yields a key intermediate with sp3‐defect heptagons, and subsequent oxidative dehydrogenation affords fully conjugated cSNG.
Felix Trautner +11 more
wiley +1 more source
Superfast Tetrazole-BCN Cycloaddition Reaction for Bioorthogonal Protein Labeling on Live Cells. [PDF]
Kumar GS, Racioppi S, Zurek E, Lin Q.
europepmc +1 more source
Catalytic Activation of Imines by Chalcogen Bond Donors in a Povarov [4+2] Cycloaddition Reaction. [PDF]
Steinke T +4 more
europepmc +1 more source
The Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction: Why Two Is Faster than One. [PDF]
Vermeeren P.
europepmc +1 more source
Hexagonal Layer Manganese Metal-Organic Framework for Photocatalytic CO2 Cycloaddition Reaction. [PDF]
Siddig LA +5 more
europepmc +1 more source
Late‐Stage Functionalization of Peptides on the Solid Phase
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source

