Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke +5 more
wiley +1 more source
On the Question of the Regio-, Stereoselectivity and the Molecular Mechanism of the (3+2) Cycloaddition Reaction Between (<i>Z</i>)-C-Phenyl-N-alkyl(phenyl)nitrones and (<i>E</i>)-3-(Methylsulfonyl)-propenoic Acid Derivatives. [PDF]
Ząbkowska M +3 more
europepmc +1 more source
A Novel Method to Construct 2-Aminobenzofurans via [4 + 1] Cycloaddition Reaction of In Situ Generated Ortho-Quinone Methides with Isocyanides. [PDF]
Lin H +6 more
europepmc +1 more source
Slow Release of Bioactive Alcohols From Butenolide Polymers and Coatings
In this study we have reported the acid‐mediated release of bioactive alcohols from biobased alkoxy butenolide derived copolymers and coatings. It can potentially be applied for slow release of odors, pesticides, or drug‐related compounds from biobased polybutenolides.
Andries Jensma +9 more
wiley +1 more source
Influence of the Nature of Group 15 Element on [Au<sup>I</sup>]-C≡E/Azide 1,3-Dipolar Cycloaddition Reaction. [PDF]
González-Pinardo D, Fernández I.
europepmc +1 more source
Unveiling the Stereoselectivity and Regioselectivity of the [3+2] Cycloaddition Reaction between N-methyl-C-4-methylphenyl-nitrone and 2-Propynamide from a MEDT Perspective. [PDF]
Salih SAM +3 more
europepmc +1 more source
The origin of the unusual regioselectivity in the Mg‐catalyzed cyclization of azadiene‐type imines with cyclopropanes is elucidated by DFT calculations. Although five‐membered rings are typically favored, energy decomposition analysis reveals that severe steric congestion induces a highly distorted transition state, rendering the five‐membered pathway ...
Ryo Kobayashi +5 more
wiley +1 more source
Synthesis and Structure Elucidation of Novel Spirooxindole Linked to Ferrocene and Triazole Systems via [3 + 2] Cycloaddition Reaction. [PDF]
Altowyan MS +5 more
europepmc +1 more source
Modeling cycloaddition reactions
Bu çalışmada, Diels-Alder ve 1,3-dipolar siklokatılmaları olmak üzere iki tip siklokatılma tepkimesinde seçicilikler incelendi.Birinci kısımda, farklı kiral dien ve akiral dienofiller kullanılarak hidrojen bağı destekli Diels-Alder reaksiyonlarındaki seçicilik Yoğunluk Fonksiyonları Teorisi (DFT) ile incelenmiştir.
openaire +1 more source
Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers
Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley +1 more source

