Results 221 to 230 of about 83,989 (313)

Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols

open access: yesChemBioChem, EarlyView.
Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen   +4 more
wiley   +1 more source

Engineering Substrate Acceptance of Resveratrol O‐Methyltransferase from Vitis vinifera for the Selective Synthesis of O‐Methyl Protected Biobased Hydroxystyrenes

open access: yesChemCatChem, EarlyView.
Reaction sequence for the synthesis of methylated products through enzymatic decarboxylation of bio‐based hydroxycinnamic acids and subsequent direct methylation of the resulting styrene intermediates without any further isolation and purification steps.
Kamela Myrtollari   +6 more
wiley   +1 more source

Organocatalytic Enantioselective Conjugate Addition of Isoxazol‐5(4H)‐Ones to Aurone‐Derived Azadienes

open access: yesChemCatChem, EarlyView.
The efficient and robust enantioselective organocatalytic methodology was developed for the conjugate addition of isoxazol‐5(4H)‐ones to aurone‐derived azadienes. This approach provided products featuring benzofuran and isoxazole rings with high yields and enantioselectivities.
Ricardo Torán   +4 more
wiley   +1 more source

Mitochondria‐Catalyzed Activation of Anticancer Prodrugs

open access: yesChemCatChem, EarlyView.
Prodrug C is a water soluble, monomeric compound accumulating in mitochondria of cancer cells, where it is activated in the reaction with mitochondrial H2O2. The activation leads to the release of camptothecin that causes cell cycle arrest in G2 phase and cancer cell death.
Michael Raucheisen   +7 more
wiley   +1 more source

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