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Pharmacokinetics and Pharmacodynamics of Valproate Analogues in Rats. IV. Anticonvulsant Action and Neurotoxocity of Octanoic Acid, Cyclohexanecarboxylic Acid, and 1‐Methyl‐1 ‐Cyclohexanecarboxylic Acid

Epilepsia, 1994
Summary: We examined the pharmacodynamics of valproate (VPA) and three structural analogues, octanoic acid (OA), cyclohexanecarboxylic acid (CCA), and 1‐methyl‐1‐cyclohexanecarboxylic acid (MCCA) in rats. A pentylenetetrazol (PTZ) infusion seizure model was used to determine threshold convulsive doses of PTZ; the increase in PTZ threshold dose after ...
M J, Liu, G M, Pollack
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The metabolism of cyclohexanecarboxylic acid and 3-cyclohexenecarboxylic acid by Pseudomonas putida

Canadian Journal of Microbiology, 1982
A strain of Pseudomonas putida grew rapidly on cyclohexanecarboxylic acid as a sole source of carbon. A CoA-mediated β-oxidation pathway was induced for the metabolism of the compound. The organism could not utilize 3-cyclohexenecarboxylic acid as a sole source of carbon for growth, but cells grown on gluconate in the presence of 3 ...
Blakley, E. R., Papish, B.
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A cyclohexanecarboxylic acid utilizing yeast: isolation, identification, and nutritional characteristics

Canadian Journal of Microbiology, 1982
A yeast capable of utilizing cyclohexanecarboxylic acid as sole carbon and energy source, strain KUY-6A, was isolated from soil by enrichment cultures. Taxonomical studies indicated that strain KUY-6A was Trichosporon cutaneum. Strain KUY-6A grew on a number of carboxylic acids.
Yoshie Hasegawa   +4 more
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The metabolism of cyclohexanecarboxylic acid in phaseolus vulgaris

Phytochemistry, 1970
Abstract Cyclohexanecarboxylic acid is converted to 1-cyclohexanecarbonyl-β- d -glucose and N -cyclohexanecarbonyl- l -aspartic acid when administered to leaf disks of Phaseolus vulgaris in the light.
J.G. Severson, B.A. Bohm, C.E. Seaforth
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Corynebacterium cyclohexanicum n. sp.: a cyclohexanecarboxylic acid utilizing bacterium

Canadian Journal of Microbiology, 1973
A cyclohexanecarboxylic acid utilizing bacterium, strain MU, has been isolated from soil and its taxonomic and physiological nature studied. The organism requires biotin or an unidentified factor present in yeast extract for growth, and can use one of various acids, alcohols, and carbohydrates as the sole carbon source.As the organism is a non-motile ...
T, Tokuyama, T, Kaneda
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The aromatization of cyclohexanecarboxylic acid to hippuric acid: substrate specificity and species differences

Molecular and Cellular Biochemistry, 1985
The ability to convert cyclohexanecarboxylic acid to hippuric acid has been studied in liver from guinea pigs, rabbits, rats and mice using a gas chromatographic - mass spectrometric method employing selected ion monitoring. Guinea pig liver showed the highest activity, giving values double of those found in rabbit liver and five times those in rat ...
A M, Svardal, R R, Scheline
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Biosynthesis of phoslactomycins: cyclohexanecarboxylic acid as the starter unit

Tetrahedron, 2003
Abstract Phoslactomycins (PLMs) A–F, produced by actinomycetes are polyketide-type antibiotics derived from a hydroxycyclohexanecarboxylic acid or a cyclohexanecarboxylic acid starter unit. Feeding experiments with [2-13C]shikimic acid indicated that the C-18 carbon of PLMs comes from C-5 of shikimate.
Yasuyo Sekiyama   +3 more
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Autoxidation of cyclohexanecarboxylic Acid‐l‐14C

Recueil des Travaux Chimiques des Pays-Bas, 1964
AbstractOxidation of cyclohexanecarboxylic acid‐1‐14C by molecular oxygen at 205°C in the presence of cupric salt of cyclohexanecarboxylic acid and magnesium oxide yielded nearly equal amounts of cyclohexanone and cyclohexene. When cupric salt and magnesium oxide were omitted, only cyclohexanone was obtained. In both cases the label distribution in the
J. A. Bigot   +2 more
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Kinetics and mechanism of coupled synthesis of cyclohexanecarboxylic acid

Russian Journal of Physical Chemistry A, 2015
The effect of the nature of the anion in a palladium salt on a coupled process involving the oxidation of CO and hydrocarboxylation of cyclohexene in the PdX2-CuBr2-THF-H2O system was studied. The kinetics was investigated under the steady-state conditions.
A. Yu. Putin   +9 more
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Conformation and reactivity. Part VI. Kinetics of the acid-catalysed esterification in methanol of the trans-decalincarboxylic acids, of the 4-t-butyl- or 2-methyl-cyclohexanecarboxylic acids, of certain trans-4-substituted cyclohexanecarboxylic acids, and of cyclohexanecarboxylic acid

Journal of the Chemical Society B: Physical Organic, 1967
The rates of acid-catalysed esterification in methanol at 30° of the trans-decalincarboxylic acids, of cis- and trans-4-t-butylcyclohexanecarboxylic acid, of cis- and trans-2-methylcyclohexanecarboxylic acid, of trans-4-X-cyclohexanecarboxylic acids (X = OH, CO2Et, CO2Me, Br, or CN), and of cyclohexanecarboxylic acid have been measured.
N. B. Chapman   +3 more
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