Results 191 to 200 of about 2,296 (262)

Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds

Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.
Geminal difunctionalization of readily available building blocks provides rapid access to molecular complexity. This work introduces a strategy for installing two distinct functional groups on a carbonyl carbon by transforming it into a donor–donor diazo compound, enabling both batch and flow applications with broad solvent compatibility.
Vincent George, Aryaman Pattanaik, Daniel Maddox, Lukas M. Sigmund, Giovanna Mejia, Sara Pahlén, Simon O. Angerer, Maria Schmoll, Lisa Marie Schneider, Nidhal Selmi, Mikhail Kabeshov, Giulia Bergonzini, Julia Rehbein, Burkhard König   +13 more
wiley   +1 more source

Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais, Rajendra Rohokale, Sevin Mamputu, Ion Lupu, Zhongwu Guo, Sébastien Balieu   +5 more
wiley   +1 more source

Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou, Kalliopi Christopoulou, Amalia D. Kalampaliki, Aikaterini F. Giannopoulou, Eleftheria Chatziorfanou, Vivi Bafiti, Andreas Krämer, Athanasios Papakyriakou, Dimitrios J. Stravopodis, Stefan Knapp, Ioannis K. Kostakis   +10 more
wiley   +1 more source

Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3–NS5 Interaction Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A synthetic methodology for the preparation of asymmetric benzene‐1,4‐disulfonamides was developed and applied to generate potential anti‐dengue virus (DENV) compounds. Guided by computer‐assisted structural rationalization, we designed synthetically more accessible analogs with reduced toxicity that interact with the DENV NS5 domain, thereby ...
Jakub Janáč, Jan Drahorád, Jakub Harvalík, Tereza Horáčková, Manfred Brinker, Arianna Loregian, Andrea Brancale, Beatrice Mercorelli, Petra Cuřínová   +8 more
wiley   +1 more source

Desymmetrization of <i>meso</i>-Pyrrolidines via Oxoammonium-Catalyzed Enantioselective Hydride Transfer. [PDF]

J Am Chem Soc
Rein J, Górski B, Keskin AM, Le MH, Lin S.   +4 more
europepmc   +1 more source

Real‐Time Monitoring of Excited‐State Ring‐Puckering Process in BODIPY Molecule Using Ultrafast Spectroscopy

ChemPhysChem, Volume 27, Issue 11, 15 June 2026.
Pyrromethene 597 (PM597), a commercial laser dye, shows a lower fluorescence yield than its analogues. Ultrafast dynamics studies using femtosecond fluorescence upconversion and transient absorption revealed that a non‐radiative ring‐puckering process in the excited state of PM597, occurring with a time constant of 1.3 ps, is primarily responsible for ...
Ayentika Sen, Aruna K. Mora, Sukhendu Nath   +2 more
wiley   +1 more source

Proline Ring‐Inversion Dynamics in Peptides Enable Cross‐Relaxation‐Based Dynamic Nuclear Polarization

ChemPhysChem, Volume 27, Issue 11, 15 June 2026.
A systematic investigation of SCREAM‐DNP beyond methyl groups, using ring‐inversion dynamics on proline as a model compound. Comparison between free proline and proline‐containing oligopeptides at different sequence positions shows how local structural context modulates ring dynamics and site‐specific DNP enhancement.
Florian Taube, Max Gierth, Georg Künze, Björn Corzilius   +3 more
wiley   +1 more source

From Citrus to Cymene: Understanding the Hydrothermal Conversion of Limonene

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
When life gives you limonene… Hydrothermal conversion and pyrolysis of limonene give two distinct sets of products, arising from differing reaction cascades. While p‐cymene dominates in the presence of water, indicative of an isomerisation/aromatisation pathway, pyrolysis favours cracking and loss of carbon affording an m‐xylene rich aromatic mix.
Jack Steel, Alexander K. L. Yuen, Alejandro Montoya, Christopher Barnett, Anthony F. Masters, Thomas Maschmeyer   +5 more
wiley   +1 more source

Nanobiocatalytic upgrading of heavy oil using <i>Geobacillus stearothermophilus</i> and alumina nanoparticles. [PDF]

RSC Adv
Maghzi A, Jafari A, Mousavi SM, Kharrat R.   +3 more
europepmc   +1 more source

MnCl2‐Catalyzed Photochemical Functionalization of Unactivated C(sp3)H Bonds

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
A photochemical method enables the activation of alkanes, utilizing cheap and abundant MnCl2 as the photocatalyst. Alkenylation and alkylation reactions are performed, affording the desired products in good yields. Activation of inert C(sp3)H bonds is of great importance in organic synthesis, since it can functionalize unreactive molecules, such as ...
Naya A. Stini, Olga G. Mountanea, Vera P. Demertzidou, Christoforos G. Kokotos   +3 more
wiley   +1 more source