Results 81 to 90 of about 2,523 (263)

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Double Reduction of Ph3B to a Dianionic Borane With a Powerful SrI Intermediate

Angewandte Chemie, EarlyView.
Although dianionic boranes follow the octet rule and are isoelectronic to carbanions or amines, the high electron density combined with the electropositive nature of the B center make them highly unstable species. In this study, we present synthesis and full characterization of a complex in which Ph3B2− is sandwiched between two Sr2+ ions and describe ...
Michael Morasch, Marcel A. Schmidt, Tanuja Tewari, Jens Langer, Sjoerd Harder   +4 more
wiley   +2 more sources

Asymmetric synthesis of multifunctional cyclopentanes and cyclohexanes via oxycarbenium ion cyclizations of 5-alkoxy- 2(3h)-dihydrofuranones

, 1995
Intramolecular nucleophilic additions to oxycarbenium ions derived from 5-alkoxy-2(3)-dihydrofuranones gave substituted cyclopentanes or cyclohexanes in good yields. Stereoselectivity in these reactions was usually very high, while regioselectivity could
Oeveren, Arjan van, Geertsema, Edzard M., Meetsma, Auke, Leung, Chiu W., Feringa, Bernard, Arjan van Oeveren, Ben L. Feringa, Auke Meetsma, Chiu W. Leung, Edzard M. Geertsema   +9 more
core   +1 more source

MoS2 Memristors Made by Liquid–Liquid Interface Assembly and Ultraprecise Metal Printing

Advanced Electronic Materials, EarlyView.
A cleanroom‐free, fully additive fabrication route combines ultraprecise printed silver electrodes with Langmuir–Schaefer‐deposited bilayer MoS2 to realize ultralow‐power resistive switching devices. The resulting microscale memories exhibit low operating voltages, a large memory window, stable retention and endurance, demonstrating a scalable and cost‐
Miguel Franco, Daniel Neves, Dorina T. Papanastasiou, Jonas Deuermeier, Tomás Calmeiro, Tomás Mingates, Adam Kelly, Joseph Neilson, Eugénie Martinez, Zdeněk Sofer, Elvira Fortunato, Rodrigo Martins, Emanuel Carlos, Asal Kiazadeh   +13 more
wiley   +1 more source

Hydration‐Gated Photoinduced Electron Transfer in BODIPY Dyes

Angewandte Chemie, EarlyView.
Hydration switches photoinduced electron transfer (PET) ON in alkoxy‐coordinated BODIPY dyes via specific hydrogen bonding. This gating yields a fluorescence lifetime span of ∼6 ns, enabling fluorescence lifetime imaging microscopy (FLIM) contrast in live cells and organoids. ABSTRACT Fluorescent probes based on photoinduced electron transfer (PET) are
Venkata N. K. Mamillapalli, Irina A. Okkelman, Fatima Akhssas, Greta Sambucari, Angela C. Debruyne, Dinesh Beniwal, Christophe Bucher, Mariangela Di Donato, Ruslan I. Dmitriev, Mikhail A. Filatov   +9 more
wiley   +2 more sources

Axially Chiral Nonalternant Polycyclic Aromatic Hydrocarbon With Consecutive Pentagons Exhibiting Large Spin‐Polarized Current

Angewandte Chemie, EarlyView.
Here we report two nonalternant polycyclic aromatic hydrocarbons (PAH) (1 and 2), which contain two and four consecutive pentagons, respectively. Under acidic conditions, 1 and 2 dimerize to afford the axially chiral dimers AC1 and AC2. The central azulene moiety in both 2 and AC2 shows an unusually short transannular bond of 1.366 Å.
Chang Wang, Jiaxin Luo, Haipeng Lu, Junzhi Liu   +3 more
wiley   +2 more sources

Theoretical Calculation of the Optical Anisotropy of Substituted Cyclohexanes and Associated Bisphenyl Molecules Using Experimentally Derived Group Polarizabilities

, 2016
A general method for the formulation of polarizability tensor and computation of optical anisotropy of a series of substituted cyclohexanes and their bisphenyl fragments, which are model analogues of corresponding polymers is presented.
U. Natarajan (3051318), M. S. Sulatha (2228995), S. Sivaram (2090290)   +2 more
core   +1 more source

Alternate Method for the Synthesis of Six-Membered Carbocycles with Five Stereocenters: 1,2,3,4,6-Pentasubstituted-4-hydroxy-cyclohexanes

, 2015
A series of novel 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes (3a–u) were synthesized from the reaction of aromatic ketones with aromatic aldehydes under mild reaction conditions in good yields.
Hayreddin Gezegen (539127), Mustafa Ceylan (539128)   +1 more
core   +2 more sources

Control of Helix Screw‐Sense Preference in Dynamic Foldamers of meso Symmetry Built From Chiral Monomeric Units

Angewandte Chemie, EarlyView.
Sequence‐diverse meso and “near‐meso” oligourea foldamers are reported and exhibit stimulus‐responsive helix screw‐sense control governed by terminal‐group desymmetrization and sequence‐encoded helix stability. ABSTRACT Meso oligoureas are dynamic hydrogen‐bonded foldamers capable of reversible helix polarity inversion but have so far been limited to ...
Naveen Gupta, Mégane Bornerie, Bo Li, Antoine Hacihasanoglu, Orlando Villegas Bello, Stéphanie Antunes, Estelle Morvan, Jean‐Marc Sotiropoulos, Philippe Carbonnière, Morgane Pasco, Brice Kauffmann, Céline Douat, Sung Hyun Yoo, Gilles Guichard   +13 more
wiley   +2 more sources

S = 3/2 Iron(I)‐Bisphosphine‐Ate Complexes: Synthesis, Characterization, and Reactivity for Electrophile Activation

Angewandte Chemie, EarlyView.
In this work, we present a new class of unusual charged Fe(I)‐bisphosphine‐ates, along with full characterization of their structure and bonding, utilizing low‐temperature synthetic and spectroscopic and techniques. These complexes are highly reactive toward catalytically relevant electrophiles, and can serve as valuable synthons providing access to ...
Egor Kokin, Shih‐Chieh Kao, Matthew J. Kania, Michael L. Neidig   +3 more
wiley   +2 more sources