Results 81 to 90 of about 2,800 (171)

A Catalytic Homo-Nazarov Cyclization Protocol for the Synthesis of Heteroaromatic Ring-Fused Cyclohexanones

, 2016
A general protocol for the catalytic homo-Nazarov cyclization of cyclopropyl heteroaryl ketones has been developed, which employs indium triflate as the promoter.
Lien H. Phun (2010691), Marchello A. Cavitt (1843138), Stefan France (1516399), Dadasaheb V. Patil (1825606)   +3 more
core   +2 more sources

Organocatalytic Formal (3+2+1)‐Cycloaddition of Allenoates, Michael Acceptors, and Carbaldehydes

Chemistry – A European Journal, Volume 32, Issue 35, 19 September 2026.
The use of secondary amine Lewis base organocatalysts allows for the unprecedented activation of allenoates for formal (3+2+1)‐cycloadditions with Michael acceptors and aromatic carbaldehydes. ABSTRACT Employing secondary amines as covalently interacting Lewis basic organocatalysts allows for the activation of electron‐deficient allenes (allenoates ...
David Naderer, Alexander Pötscher, Katharina Eder, Uwe Monkowius, Markus Himmelsbach, Mario Waser   +5 more
wiley   +1 more source

Strategy for Contiguous Tetramination of Cyclohexanones with o‑Phenylenediamines with Elemental Sulfur and DMSO

, 2019
The S8/DMSO combination was found to be an excellent oxidizing agent for ipso,α,β,γ-tetramination of cyclohexanones with two molecules of o-phenylenediamines in the presence of TFA as a catalyst.
Le Anh Nguyen (7139885), Thanh Binh Nguyen (1508308), Pascal Retailleau (1445848)   +2 more
core   +1 more source

Molecular Iodine-Catalyzed Aerobic α,β-Diamination of Cyclohexanones with 2‑Aminopyrimidine and 2‑Aminopyridines

, 2016
Molecular iodine is shown to be an excellent catalyst for aerobic oxidative α,β-diamination of cyclohexanones with 2-aminopyrimidine/2-aminopyridines.
Al-Mourabit, Ali, Nguyen, T .B., Ali Al-Mourabit (1508305), Pascal Retailleau (1445848), Retailleau, Pascal,, Ludmila Ermolenko (1508299), Nguyen, Thanh Binh,, Thanh Binh Nguyen, Ermolenko, Ludmila, Thanh Binh Nguyen (1508308), Ludmila Ermolenko, Retailleau, Pascal, ́, Ali Al-Mourabit, Pascal Retailleau   +13 more
core   +2 more sources

Chemoselective Aldehyde and Imine Reduction by a Macrocyclic Triazole–Borane Complex Triggered by a Non‐innocent Proton–Hydride Interaction

European Journal of Organic Chemistry, Volume 29, Issue 35, 19 September 2026.
This work describes the study on a new recyclable reagent, based on a macrocyclic triazole–borane complex. It showed high chemoselectivity for aldehyde reduction and reductive amination over ketones. This selectivity is driven by a noncovalent hydride–proton interaction that stabilizes the transition state for aldehydes but is sterically inhibited in ...
Luca Di Marino, Artur Brotons Rufes, Rosaria Schettini, Giorgio Della Sala, Francesco De Riccardis, Chiara Costabile, Irene Izzo   +6 more
wiley   +1 more source

Asymmetric Wittig reaction of chiral arsonium ylides - I. Asymmetric olefination of 4-substituted cyclohexanones

, 1997
Asymmetric Wittig-type olefination of 4-substituted cyclohexanones with chiral ligand-modified stable arsonium ylides has been examined. The 8-phenylmenthol-derived chiral arsonium ylide of 4 reacted with prochiral ketones 9a-d at -15°C to give the 4 ...
Dai, Wei Min, Wu, Jinlong, Huang, Xian
core   +1 more source

Next‐Generation Manufacturing: The Evolving Role of Biocatalysis in AstraZeneca

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
Biocatalysis is strengthening AstraZeneca's manufacture of active pharmaceutical ingredients through faster development, robust scale‐up, and lower environmental impact. Case studies illustrate where biocatalysis delivers greatest value, while enabling platforms, teams, and partnerships shape its next phase.
Alba Diaz‐Rodriguez, Martin A. Hayes, Keith R. Mulholland, Fernando Tur, Samantha Staniland   +4 more
wiley   +1 more source

Metal-Free Synthesis of 2‑Aminobenzothiazoles via Aerobic Oxidative Cyclization/Dehydrogenation of Cyclohexanones and Thioureas

, 2016
A metal-free process for the synthesis of 2-aminobenzothiazoles from cyclohexanones and thioureas has been developed using catalytic iodine and molecular oxygen as the oxidant under mild conditions.
Huoji Chen (1554802), Huawen Huang (1427662), Jinwu Zhao (1867384), Wanqing Wu (796508), Huanfeng Jiang (1392913)   +4 more
core   +1 more source

Highly enantio- and diastereoselective organocatalytic desymmetrization of prochiral cyclohexanones by simple direct aldol reaction catalyzed by proline

, 2009
Panacea for aldol desymmetrizations: we describe an easy entry for the desymmetrization of 4-substituted-cyclohexanones catalyzed by proline, using as cocatalysts different hydrogen-bonding donors (see scheme), which dramatically improves the catalytic ...
Luis Crovetto, Xavier Companyó, Guillem Valero, Albert Moyano, Companyó, Xavier, Ramon Rios, Moyano, Albert, Rios, Ramon, Crovetto, Luis, Valero, Guillem   +9 more
core   +1 more source

Diels-alder Reactions of 2-azadienes - Diastereoselective Syntheses of 2-azabicyclo[2.2.2]octan-2-ones and of 2,3,4-substituted Cyclohexanones

, 1988
Glutarimide is readily disilylated to yield the cyclic 2-azadiene which reacts with open-chain dienophiles with surprisingly high exo-selectivity.
Rivera, M., F. Sainte, K. Mbiya, Lamyschelkens, H., H. Lamy-Schelkens, Ghosez, Léon, M. Rivera, L. Ghosez, Sainte, Francy, Mbiya, K.   +9 more
core   +1 more source