Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis
We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley +1 more source
A Hoveyda–Grubbs‐Type Olefin Metathesis Catalyst Bearing a Fluorinated Unsymmetrical NHC Ligand
A fluorinated unsymmetrical NHC ruthenium complex was synthesised and employed as a catalyst for olefin metathesis reactions. The modification of the steric and electronic properties of the NHC ligand through the introduction of fluorine substituents results in improved activity but lower selectivity compared to the analogous non‐fluorinated NHC ...
Rubina Troiano +3 more
wiley +1 more source
Late-Stage Molecular Editing Enabled by Ketone Chain-Walking Isomerization. [PDF]
Brägger Y +3 more
europepmc +1 more source
Heterogeneously Catalyzed Selective Acceptorless Dehydrogenative Aromatization to Primary Anilines from Ammonia via Concerted Catalysis and Adsorption Control. [PDF]
Li H, Yatabe T, Takayama S, Yamaguchi K.
europepmc +1 more source
Selective Synthesis of Chiral Carbocycles by Iridium-Catalyzed Asymmetric Mono-, Double-, or Triple Hydrogenation of Cyclic Dienones. [PDF]
Peters BBC +3 more
europepmc +1 more source
To PLP or Not to PLP: Stereodivergent Transaminase-Catalyzed Reactions Directed by Kinetic and Thermodynamic Control. [PDF]
Fitzgerald MJ +8 more
europepmc +1 more source
Three decades of selective product formation <i>via</i> Griesbaum co-ozonolysis: insight and advances (1995-2025). [PDF]
Zain-Ul-Abideen M +4 more
europepmc +1 more source
Non-chelation control in allylations of α-oxy ketones using group-14 allylatranes. [PDF]
Tsutsui Y, Shiga K, Konishi A, Yasuda M.
europepmc +1 more source
Cascade Grignard Addition: Propargyl Claisen Rearrangement for the Stereoselective Synthesis of α-Allene Quaternary Centers in Cyclohexanones. [PDF]
Armendariz-Gonzalez E +8 more
europepmc +1 more source

