Results 61 to 70 of about 2,800 (171)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Water‐Derived Radical Species Initiate Six‐Electron Oxidation of Cyclic Ketones in Microdroplets

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
Spontaneous six‐electron oxidation of cyclic ketones to yield dicarboxylic acids/keto acids is achieved in ethanol microdroplets containing about 2% water under ambient conditions without any metal salts, acids, or oxidants. Mechanistic studies show that trace amounts of water and molecular oxygen serve as active oxidants in this transformation ...
Muhammad Mujahid Ali, Manish Jana, William LeFever, Robert Graham Cooks   +3 more
wiley   +2 more sources

Advances in organic UV filters for sunscreens over the past decade

Photochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon, Maria Carolina Theisen, Andressa Motta Castro, Giovana Jones Radke, Fernando Fumagalli   +4 more
wiley   +1 more source

The Natural Product Esculetin as an Efficient Photoacid for the Visible‐Light‐Mediated Acetalization/Ketalization Reaction

ChemSusChem, Volume 19, Issue 19, 14 October 2026.
Esculetin: an efficient photoacid catalyzing acetalization/ketalization reactions. The development of photochemical protocols for the production of fine chemicals and industrially interesting products, employing sustainable catalysts under mild conditions, is of high interest.
Maria A. Theodoropoulou, E. Alexandros Routsi, Christiana Mantzourani, Olga G. Mountanea, Demeter Tzeli, Christoforos G. Kokotos, George Kokotos   +6 more
wiley   +1 more source

Halogenated terpenoids: VIII. The halogenation of some axial α-bromo-p-menthanones. Boat conformers of halogenated cyclohexanones

, 1973
The structures of some halogenated p-menthan-2-ones and p-menthan-3-ones are determined. Some cyclohexanones with α-axial bromine and α'- equatorial bromine substituents exist in a boat conformation provided an additional attractive halogen→carbonyl ...
BN Venzke, RM Carman, Carman, R. M., Venzke, B. N.   +3 more
core   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2629-2642, October 2026.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Asymmetric Organocatalytic Double-Conjugate Addition of Malononitrile to Dienones: Efficient Synthesis of Optically Active Cyclohexanones

, 2016
9-Amino-9-deoxyepiquinine efficiently catalyzed the double-conjugate addition of malononitrile to dienones. A number of 1,1,2,6-tetrasubstituted cyclohexanones were prepared in good yields, diastereoselectivities, and excellent ...
Bo Wang (86769), Ming Yan (284631), Xue-ming Li (2233780), Jun-min Zhang (2233783)   +3 more
core   +1 more source

Complementary Breath Profiling Using eNose and Gas Chromatography‐Mass Spectrometry for Noninvasive Triage of Indeterminate Pulmonary Nodules

MedComm, Volume 7, Issue 10, October 2026.
Flow diagram illustrating participant inclusion and exclusion for the eNose and GC‐MS analyses. Of the 98 prospectively enrolled participants, 79 were eligible for the eNose analysis after the exclusion of 14 participants because of procedural or eligibility issues, four without breath samples, and one without a valid eNose recording.
Waqar Ahmed Afridi, Gunter Hartel, Xi Zhang, David Pass, David Fielding, Chamindie Punyadeera   +5 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Regiochemistry of the condensation of 2-aroyl-cyclohexanones and 2-cyanoacetamide: 13C-labeling studies and semi-empirical MO calculations

, 2012
Hydroxy-aryl-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles represent interesting chemical scaffolds, but synthetic access to these compounds is limited.
van Linden, O.P.J., de Esch, I.J.P.; id_orcid, Rotteveel, L., van Linden, O.P.J.; id_orcid, Wijtmans, M., Esch, I.J.P. de, Roumen, L., de Esch, I.J.P., Linden, O.P.J. van, Leurs, R.   +9 more
core   +1 more source