Results 141 to 150 of about 109,753 (261)

Cyclooxygenase-2 (COX-2) as a Potential Prognostic Marker in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. [PDF]

Health Sci Rep
Qasem HM, Odat RM, Alshwayyat S, Younis OM, Yasin JA, Hussein AM, Hammadeh BM, Ghlailat M, Amayreh LA, Yadav R, Nguyen D, Jain H, Kelkar R.   +12 more
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Chrysotoxine Attenuates Key Atherogenic Processes via Antioxidant, Anti-Inflammatory, and COX-Dependent Antiplatelet Mechanisms. [PDF]

Biomolecules
Rustamani F, Swe HN, Thant SW, Moonrut J, Sritularak B, Rojnuckarin P, Nalinratana N, Luechapudiporn R.   +7 more
europepmc   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Repurposing piroxicam for antithrombotic and cardiopulmonary protection: Pharmacological rationale and therapeutic potential. [PDF]

Indian J Pharmacol
Khalid W, Khan AU.
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Analysis of Two New Flavonoid Glycosides From <i>Zanha golungensis</i> Hiern With COX Inhibition Activity: Structural Elucidation, DFT Calculations, In Vitro and Molecular Docking Assessment. [PDF]

Anal Sci Adv
Zeuikena J, Feunaing RT, Tamfu AN, Gbaweng AJY, Henoumont C, Laurent S, Anouar EH, Talla E.   +7 more
europepmc   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Direct Oral Anticoagulants, COX-2-Selective NSAIDs, and Gastrointestinal Bleeding in Atrial Fibrillation.

JAMA Netw Open
Meinert FM, Dimakos J, Cui Y, Filion KB, Renoux C, Douros A.   +5 more
europepmc   +1 more source

Targeting Oxidative Stress and Inflammation in Pembrolizumab-Induced Renal Injury: A Comparative Evaluation of the Protective Effects of Flunarizine and Carvacrol in Rats. [PDF]

Biomolecules
Hendem E, Yavuzer B, Sezgin ET, Gunay M, Ozkaraca M, Gungor A, Altuner D, Suleyman H.   +7 more
europepmc   +1 more source