Results 271 to 280 of about 231,004 (334)

MDP25‐VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis

Advanced Science, EarlyView.
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou, Pengfei Lu, Xuan Cui, Liangfeng Luo, Qing Pan, Jiejie Li   +5 more
wiley   +1 more source

Synthesis of novel phenoxyacetohydrazide compounds and evaluation therapeutic potential exhibit as anti-inflammatory and anti-angiogenic. [PDF]

PLoS One
Mohammed YHI, Shntaif AH, Alghamdi S, Mansour AA, Qusty NF, Sindi AS, Babalghith AO, Bamagous GA, Abu-Seer EA.   +8 more
europepmc   +1 more source

Synthesis of E-stilbens as Potent Cyclooxygenase-2 Inhibitors and Identification of their Photochemical Products [PDF]

, 2014
Ahmadreza Bekhradnia, Maryam Ahmadian Moghadam, Monire Tatar   +2 more
openalex  

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Evaluation of <i>Callistemon citrinus</i> Compounds to Reduce Brain Oxidative Stress in Rats Fed High-Fat-Sucrose Diet. [PDF]

Metabolites
García-Calderón AJ, Magaña-Rodríguez OR, Ayala-Ruiz LA, Hernández-Soto JA, Piñón-Simental JS, Ortega-Pérez LG, Aguilera-Méndez A, Ríos-Chávez P.   +7 more
europepmc   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Erratum: "Dysregulation of lipid mediators in patients with frequent exacerbations of COPD" Marie Fisk, Esteban A. Gomez, Yuan Sun, Monika Mickute, Carmel McEniery, John R. Cockcroft, Charlotte Bolton, Jonathan Fuld, Joseph Cheriyan, Yasmin, William MacNee, Ruth Tal-Singer, Michael Polkey, Ian Wilkinson and Jesmond Dalli. <i>ERJ Open Res</i> 2025; 11: 00950-2023. [PDF]

ERJ Open Res
europepmc   +1 more source

Allergy to acetylsalicylic acid among patients with acute coronary syndrome. [PDF]

CMAJ
Haddad A, Mir A, Copaescu AM.
europepmc   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Design and synthesis of novel spirocyclic oxindole based hybrid scaffolds: <i>in silico</i> docking approach towards therapeutic target exploration. [PDF]

RSC Adv
Upadhyay RK, Saini KK, Kant R, Chaudhary N, Tonger Y, Kumar A, Kumar R.   +6 more
europepmc   +1 more source