Results 101 to 110 of about 23,800,079 (261)
Jurnal Kimia Valensi, 2018 Inflammation is a response to tissue injury involving the physiological process of cyclooxygenase enzyme activation which has two isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. The use of anti-inflammatory drugs of Non Steroidal
Rizky Arcinthya Rachmania +3 more
doaj +1 more source
Catalytic covalent inhibition of cyclooxygenase-1 by a biomimetic acyltransferase. [PDF]
Bioorg Med Chem, 2022 Bao W, Turniansky B, Koh J.
europepmc +1 more source
Celecoxib in breast cancer prevention and therapy. [PDF]
, 2018 Breast cancer has a high incidence worldwide. The results of substantial studis reveal that inflammation plays an important role in the initiation, development, and aggressiveness of many malignancies. The use of celecoxib, a novel NSAID, is repetitively
Cao, Wei +4 more
core
Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid
Aging, 2009 Several independent epidemiological studies indicate that chronic use of non-steroidal anti-inflammatory drugs can reduce the risk of developing Alzheimer's disease (AD), supporting the inflammatory cascade hypothesis.
Sang-H. Choi, F. Bosetti
semanticscholar +1 more source
Indonesian Journal of Chemistry, 2010 The docking protocols to virtually screen selective cyclooxygenase-2 (COX-2) ligands using PLANTS docking software were developed and validated. The crystal structure of 1-phenylsulfonamide-3-trifluoromethyl-5-parabromophenyl-pyrazole (S58) binds to ...
Stefanus Layli Prasojo +4 more
doaj +1 more source
Flavanones from Sorghum bicolor selectively inhibit COX-2: in-silico and in-vivo validation
Egyptian Journal of Medical Human Genetics, 2019 Background COX-2-specific inhibitors offer improved advantages over traditional NSAIDs. Plants are known to play critical roles in the discovery and developments of new pharmaceuticals.
O. Adeboye Akinloye +8 more
doaj +1 more source
Identification of Novel Cyclooxygenase-1 Selective Inhibitors of Thiadiazole-Based Scaffold as Potent Anti-Inflammatory Agents with Safety Gastric and Cytotoxic Profile. [PDF]
Molecules, 2023 Haroun M +15 more
europepmc +1 more source
Compensatory Prostaglandin E2 Biosynthesis in Cyclooxygenase 1 or 2 Null Cells [PDF]
, 1998 Kanyawim Kirtikara +6 more
openalex +1 more source
Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia?
American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2009 Systemic inflammation is associated with either fever or hypothermia. Fever, a response to mild systemic inflammation, is mediated by cyclooxygenase (COX)-2 and not by COX-1. However, it is still disputed whether COX-2, COX-1, neither, or both mediate(s)
A. Steiner +8 more
semanticscholar +1 more source
Iraqi Journal of Pharmaceutical Sciences, 2017 This study includes design and synthesis of new non-steroidal anti-inflammatory agents (NSAIDs) with expected cyclooxygenase-2 (COX-2) selective inhibition to achieve better activity and low gastric side effects.
Nadeem A. Abdul Razzak +2 more
doaj +1 more source