Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway [PDF]
, 2006 We report a multiwavelength (X-ray, ultraviolet/optical/infrared, radio) analysis of the relativistic tidal disruption event candidate Sw J2058+05 from 3 months to 3 yr post-discovery in order to study its properties and compare its behavior with that of
Bower, Geoffrey C. +15 more
core +4 more sources
gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect
BMC Chemistry, 2019 Introduction New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages.
Abeer J. Ayoub +11 more
doaj +1 more source
Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma [PDF]
International Journal of Colorectal Disease, 2009 Cyclooxygenase (COX) enzymes, COX1 and COX2, are key in converting arachidonic acid (AA) into prostaglandins that have been associated with colorectal carcinogenesis. The aim of our study was to investigate associations of polymorphisms in COX genes, alone and in interaction with exposures known to be related to inflammation and AA metabolism, with ...
Gong, Zhihong +7 more
openaire +3 more sources
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]
, 2007 Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico +8 more
core +1 more source
Discovery of potential cyclooxygenase inhibitors using in silico docking studies
Bangladesh Journal of Pharmacology, 2012 This study deals with the evaluation of the cyclooxygenase inhibitory activity of flavonoids (tangeritin, morin, rhamnetin, theaflavin, pachypodol, eriodictyol, homoeriodictyol, aromadedrin, okanin) using in silico docking studies.
Arumugam Madeswaran +5 more
doaj +1 more source
Association of Cyclooxygenase-2 Expression With Endoplasmic Reticulum Stress and Autophagy in Triple-Negative Breast Cancer [PDF]
, 2023 Cyclooxygenase-2 plays a role in oncogenesis and its overexpression is associated with triple-negative breast cancer. However, the mechanisms whereby cyclooxygenase-2 contribute to breast cancer are complex and not well understood.
Gong, Gyungyub +4 more
core +1 more source
Cerebral Cortex, 2011 Functional hyperemia, the brain's capability to alter microvascular blood flow in response to the metabolic demands of active neurons, is essential for sustained mammalian brain function.
T. Hahn +5 more
semanticscholar +1 more source
NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2.
Gastroenterology, 2000 BACKGROUND & AIMS Selective cyclooxygenase (COX)-2 inhibitors produce less gastric damage than conventional nonsteroidal anti-inflammatory drugs (NSAIDs), suggesting that NSAIDs cause damage by inhibiting COX-1. We tested this hypothesis in rats by using
J. Wallace +3 more
semanticscholar +1 more source
Modulation of the UVA activation of haem oxygenase, collagenase and cyclooxygenase gene expression by epigallocatechin in human skin cells [PDF]
, 1998 We have investigated the modifying effects of epigallocatechin, a major polyphenolic constituent of green tea, on ultraviolet-A-activated gene expression in human fibroblasts and keratinocytes using the stress responsive enzymes: haem oxygenase-1 ...
Rice-Evans, Catherine +2 more
core +1 more source
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]
, 2004 Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo +4 more
core +1 more source