Results 71 to 80 of about 23,800,079 (261)

Clinicopathologic Association of Cyclooxygenase 1 and Cyclooxygenase 2 Expression in Gastric Adenocarcinoma

Annals of Surgery, 2001
To evaluate the association of clinicopathologic factors and prognostic value with the expression of cyclooxygenase 1 and 2 in patients with gastric adenocarcinoma.Epidemiologic studies have indicated that nonsteroidal antiinflammatory drugs reduce the risk of colon cancer by as much as 40% and also decrease the risk of gastric cancer.
Chen, Chiung-Nien, Sung, Chia-Tung, Lin, Ming-Tsan, Lee, Po-Huang, Chang, King-Jen   +4 more
openaire   +4 more sources

Docking studies of some pyrazole containing compounds in the cyclooxygenase-2 active site [PDF]

Arhiv za farmaciju, 2023
Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors target cyclooxygenase-2, which is overexpressed in inflammation, but ...
Savić Jelena, Antonijević Marija, Crevar Milkica, Brborić Jasmina   +3 more
doaj  

Cyclooxygenases: Proliferation and differentiation [PDF]

, 2016
Prostaglandins are formed from arachidonic acid by the action of cyclooxygenase and subsequent downstream synthetases. Mainly two cyclooxygenase isoforms have been identified which are now known as cyclooxygenase-1 and cyclooxygenase-2.
Ashtiani, Hamid Reza Ahmadi, Bakhshandi, Ali Karimi, Mirzaei, Akram, Rastegar, Hossein   +3 more
core   +2 more sources

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

Journal of Clinical Investigation, 1994
High levels of immunoreactive cyclooxygenase (Cox; prostaglandin H synthase) are present in synovia from patients with rheumatoid arthritis (RA). We now show that the recently identified inducible isoform of Cox, Cox-2, is expressed in synovia from ...
L. Crofford, R. Wilder, A. Ristimäki, H. Sano, E. Remmers, H. Epps, T. Hla   +6 more
semanticscholar   +1 more source

In vitro and In Silico Studies on Curcumin and Its Analogues as Dual Inhibitors for cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2)

Journal of Mathematical and Fundamental Sciences, 2013
Curcumin has been widely reported as an anti-inflammatory agent isolated from the plant Curcuma longa L. (turmeric). This anti-inflammatory activity was associated with the ability of this compound to inhibit the activity of both cyclooxygenase-1 (COX-1)
Nunung Yuniarti, Perdana Adhi Nugroho, Aditya Asyhar, Sardjiman Sardjiman, Zullies Ikawati, Enade Perdana Istyastono   +5 more
doaj   +1 more source

Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1. [PDF]

PLoS ONE, 2014
Platelet aggregation during aspirin treatment displays considerable inter-individual variability. A genetic etiology likely exists, but it remains unclear to what extent genetic polymorphisms determine platelet aggregation in aspirin-treated individuals ...
Morten Würtz, Peter H Nissen, Erik Lerkevang Grove, Steen Dalby Kristensen, Anne-Mette Hvas   +4 more
doaj   +1 more source

Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection.

Viral immunology, 2010
Prostaglandins (PGs) play an important role in pulmonary physiology and various pathophysiological processes following infection. The initial step in the biosynthesis of PGs is regulated by two distinct cyclooxygenase enzymes, cyclooxygenase-1 (COX-1 ...
Z. Radi, D. Meyerholz, M. Ackermann
semanticscholar   +1 more source

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response [PDF]

, 2002
Objective: Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for functional variants that may influence susceptibility to disease.
Brull, D.J., Hill, M.R., Humphries, S.E., Laurent, G.J., Marshall, R.P., McAnulty, R.J., Papafili, A.   +6 more
core   +1 more source

Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity

Drug Design, Development and Therapy, 2023
Guojin Ren,1,* Qili Zhang,1,2,* Pengfei Xia,1– 4 Jie Wang,1 Pengxia Fang,1 Xiaojie Jin,1 Xuejing Peng,1– 4 Yanli Xu,1,5 Jian Zhang,1– 4 Lei Zhao1– 5 1Gansu University of Chinese Medicine, Lanzhou, 730000, People’s Republic of China; 2Northwest ...
Ren G, Zhang Q, Xia P, Wang J, Fang P, Jin X, Peng X, Xu Y, Zhang J, Zhao L   +9 more
doaj  

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs [PDF]

, 2014
© 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.BACKGROUND: Cardiovascular ...
Ahmetaj-Shala, Blerina, Al'Yamani, Malak, Armstrong, Paul C. J., Kirkby, Nicholas S., Knowles, Rebecca, Leiper, James, Mackenzie, Louise, Mazi, Sarah, Mitchell, Jane A., Nüsing, Rolf M., Tomlinson, James A. P., Tucker, Arthur T., Wang, Zhen, Warner, Timothy D.   +13 more
core   +3 more sources