Results 291 to 300 of about 207,862 (335)

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

Advanced Science, EarlyView.
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen, Ze Wang, Chenglong Sun, Yang Zhong, Yuan Liu, Yikun Li, Tongchao Zhang, Yuan Zhang, Xingyu Zhu, Leping Li, Feifei Teng, Ming Lu, Wei Chong   +12 more
wiley   +1 more source

Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2. [PDF]

Eur J Med Res
Cao S, Li H, Ye X, Xing X, Xie Y, Zeng X, Liu H, Zhong X, Yang X, Xing W, Zhu C, Wu X.   +11 more
europepmc   +1 more source

Garlic peel extract as an antioxidant inhibits triple-negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase-2 expression. [PDF]

Food Sci Nutr
Dong Y, Zhang J, Xie A, Yue X, Li M, Zhou Q.   +5 more
europepmc   +1 more source

Synthesis and elucidation of strained galactopyronose esters as selective cyclooxygenase-2 inhibitor: a comprehensive computational approach. [PDF]

RSC Adv
Musa MS, Miah MS, Munni YA, Patwary MAM, Kazi M, Matin MM.   +5 more
europepmc   +1 more source

Fuzheng Xuanfei Huashi prescription suppresses inflammation in lipopolysaccharide-induced lung injury in mice toll-like recptor 4/nuclear transcription factor κB and cyclooxygenase-2/prostaglandin E2 pathway. [PDF]

J Tradit Chin Med
Haiyang H, Shumin Z, Shaowen Z, Ying L, Shaozhen H, Jie G, Jianzhao OU, Mingguo D, Weimin N.   +8 more
europepmc   +1 more source

A Novel Platform Featuring Nanomagnetic Ligand Fishing Based on Fixed-Orientation Immobilized Magnetic Beads for Screening Potential Cyclooxygenase-2 Inhibitors from Panax notoginseng Leaves. [PDF]

Molecules
Zhang F, Sun F, Yu L, Li F, Liu L, Cao X, Zhang Y, Wu L.   +7 more
europepmc   +1 more source

Chalcone derivatives' interaction with human serum albumin and cyclooxygenase-2. [PDF]

RSC Adv
Karthikeyan S, Thirunarayanan A, Shano LB, Hemamalini A, Sundaramoorthy A, Mangaiyarkarasi R, Abu N, Ganesan S, Chinnathambi S, Pandian GN.   +9 more
europepmc   +1 more source

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Cyclooxygenase-2 and atherosclerosis

Current Opinion in Lipidology, 2002
Cyclooxygenase regulates the production of eicosanoids, which modulate physiologic processes in the vessel wall contributing to atherosclerosis and thrombosis, including platelet aggregation, control of vascular tone, and the local inflammatory response.
MacRae F. Linton, Sergio Fazio
openaire   +4 more sources