Results 211 to 220 of about 24,904,492 (241)

Light-Promoted C-H/C-H Coupling of Imidazo[1,2-<i>a</i>]pyridines with 5-(Hetero)aryl-1,2,5-oxadiazolo[3,4-<i>b</i>]pyrazines over TiO₂ and Experimental/In Silico Evaluation of COX-1 and COX-2 Inhibitory Activity. [PDF]

Molecules
Trestsova MA, Andreeva DA, Kiskin MA, Komelkova MV, Vassiliev PM, Taran AS, Yolshina LA, Kvashnichev AG, Isaeva VA, Utepova IA, Chupakhin ON, Sarapultsev AP.   +11 more
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

What Do We Know About Cyclooxygenases Expression in the Lower Urinary Tract of Dogs and Cats? A Systematic Review. [PDF]

J Vet Pharmacol Ther
de Moraes RS, Benevenuto LGD, da Rocha Cesario AGG, Ferreira JF, Maia SR, Regalin D, de Souza Ramos DG, Melchert A, Guimarães-Okamoto PTC.   +8 more
europepmc   +1 more source

In Silico Analysis of Enantioselective Binding of Pomalidomide Targets for Multiple Myeloma. [PDF]

Chirality
Vardhan G, Kumar V, Kumar A, Handu S, Dhamija P.   +4 more
europepmc   +1 more source

Discovery of New Pyrazole-Linked Pyridine Derivatives as Multi-Target Anti-Inflammatory Agents With Immunomodulatory Potential. [PDF]

Drug Dev Res
Salem MA, Raslan RR, Gohar NA, Abusaif MS, Ammar YA, Ragab A.   +5 more
europepmc   +1 more source

In Vitro Anti-Inflammatory Activity of Sour Cherry (Prunus cerasus L.) Seed Oil and Computational Safety Profiling. [PDF]

Chem Biodivers
Aydin T, Günbatan T, Berkkan A, Ulutaş OK, Sucu M.   +4 more
europepmc   +1 more source