Results 131 to 140 of about 2,867,692 (324)

Effects of TZI-41127, inhibitor of 5-1ipoxygenase, and TZI-41078,dual inhibitor of 5-1ipoxygenase and cyclooxygenase, on active oxygen production

, 1988
Motohiro Kobayashi, Masakatsu Nozaki, Kaito Tsurumi, Takashi Mikami, Katsuhiko Miyasaka   +4 more
openalex   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

INFLUENCE OF CYCLOOXYGENASE INHIBITORS ON PLASMA VOLUME AND PROTEIN DURING PROGRESSIVE EXERCISE

, 1984
James M. Pivarnik, Thomas Kayrouz, L. C. Senay   +2 more
openalex   +1 more source

Effect of the specific cyclooxygenase-2 inhibitor meloxicam on tumour growth and cachexia in a murine model [PDF]

, 2000
HJ Hussey, Michael J. Tisdale
openalex   +1 more source

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Piperazinealkanol Ester Derivatives of Indomethacin as Dual Inhibitors of 5-Lipoxygenase and Cyclooxygenase.

, 1994
Ichiro Yamawaki, Masataka Suzuki, Kazumi Ogawa   +2 more
openalex   +2 more sources

Intrathecal cyclooxygenase inhibitor administration attenuates morphine antinociceptive tolerance in rats [PDF]

, 2000
Chih‐Shung Wong, Ming‐Man Hsu, Robert Chang-Chih Chou, Yen‐Yen Chou, C.‐S. TUNG   +4 more
openalex   +1 more source

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source

A useful method for evaluation of difference in anti-inflammatory activities between of 5-lipoxygenase and cyclooxygenase inhibitors.

, 1993
Satoru Motoyoshi, Joe Kawata, Hiroyo Nakagawa, Katsumi Ishii, Kunihiko Takeyama   +4 more
openalex   +1 more source

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source