Results 261 to 270 of about 114,365 (325)

In Vitro Effects of VA441, a New Selective Cyclooxygenase-2 Inhibitor, on Human Osteoarthritic Chondrocytes exposed to IL-1^|^beta;

, 2012
Antonella Fioravanti, Laura Tinti, Nicola Antonio Pascarelli, Angela Di Capua, Antonello Lamboglia, Andrea Cappelli, Mariangela Biava, Antonio Giordani, S. Niccolini, Mauro Galeazzi, Maurizio Anzini   +10 more
openalex   +2 more sources

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

From Vascular Dysfunction to Atherothrombosis: The Pivotal Role of Eicosanoids and Their Receptors in Platelet and Endothelial Imbalance: A Scoping Review. [PDF]

Int J Mol Sci
Ritorto G, Ussia S, Macrì R, Serra M, Tavernese A, Altomare C, Dardano DM, Idone C, Palma E, Muscoli C, Volterrani M, Barillà F, Mollace V, Mollace R.   +13 more
europepmc   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Biological evaluation and molecular Docking studies of the prepared chalcone derivatives as potential anti-Alzheimer agents. [PDF]

Sci Rep
Agbo EN, Maluleke BK, Gildenhuys S, Leboho TC, Nxumalo W.   +4 more
europepmc   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Efficacy of Vonoprazan in Nonsteroidal Anti-Inflammatory Drug-Induced Ulcer in Terms of Ulcer Recurrence and Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis. [PDF]

Gastroenterol Res Pract
Bandyopadhyay S, Samajdar SS, Das S.
europepmc   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source

Aspirin inhibition and recovery of cyclooxygenase activity and thromboxane biosynthesis in human megakaryocytes: a translational surrogate model. [PDF]

J Pharmacol Exp Ther
Mallah ZI, Petrucci G, Ayoub AJ, Farhoud MA, Jelwan JG, Lucchisani S, Fakih AK, Badran B, Hamade E, Patrono C, Rocca B, Habib A.   +11 more
europepmc   +1 more source

Analgesic Efficacy of Firocoxib, a Selective Inhibitor of Cyclooxygenase 2, in a Mouse Model of Incisional Pain.

, 2015
Balagangadharreddy Reddyjarugu, Todd Pavek, Teresa Southard, Jason Barry, Bhupinder Singh   +4 more
openalex   +1 more source