Results 271 to 280 of about 2,867,692 (324)
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Cyclooxygenase Inhibitors and Cancer: The Missing Pieces
Journal of Pharmacology and Experimental Therapeutics, 2023At 125, aspirin still represents the cornerstone of anti-platelet therapy for the acute treatment and long-term prevention of atherothrombosis. The development of a selective regimen of low-dose aspirin for the inhibition of platelet thromboxane ...
C. Patrono
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Pain, 2018
Most advanced knee osteoarthritis (OA) patients experience chronic pain resistant to cyclooxygenase (COX) inhibitors. However, the cells and molecules involved in this advanced OA pain remain poorly understood.
Yusuke Sakurai +12 more
semanticscholar +1 more source
Most advanced knee osteoarthritis (OA) patients experience chronic pain resistant to cyclooxygenase (COX) inhibitors. However, the cells and molecules involved in this advanced OA pain remain poorly understood.
Yusuke Sakurai +12 more
semanticscholar +1 more source
Current Opinion in Internal Medicine, 2006
The purpose of this review is to summarize new information regarding the use of selective inhibitors of the cyclooxygenase-2 enzyme, emphasizing recent developments regarding cardiovascular risk.Selective cyclooxygenase-2 inhibitors are as effective as nonselective nonsteroidal antiinflammatory drugs in relieving pain and inflammation but are ...
Paul Fortun, Christopher J. Hawkey
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The purpose of this review is to summarize new information regarding the use of selective inhibitors of the cyclooxygenase-2 enzyme, emphasizing recent developments regarding cardiovascular risk.Selective cyclooxygenase-2 inhibitors are as effective as nonselective nonsteroidal antiinflammatory drugs in relieving pain and inflammation but are ...
Paul Fortun, Christopher J. Hawkey
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Pharmacodynamic of cyclooxygenase inhibitors in humans
Prostaglandins & Other Lipid Mediators, 2007We provide comprehensive knowledge on the differential regulation of expression and catalysis of cyclooxygenase (COX)-1 and COX-2 in health and disease which represents an essential requirement to read out the clinical consequences of selective and nonselective inhibition of COX-isozymes in humans.
CAPONE ML +5 more
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The Coxibs, Selective Inhibitors of Cyclooxygenase-2
New England Journal of Medicine, 2001Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual pain, and headache. Although they are effective, their long-term use is limited by gastrointestinal effects such as dyspepsia and abdominal pain and, less often, gastric or duodenal perforation or bleeding.
FitzGerald, Garret A., Patrono, Carlo
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2001
Publisher Summary This chapter deals with aspects of the discovery and development of Cyclooxygenase-2 (Cox-2) inhibitors, which, in the case of rofecoxib, resulted from efforts that were initiated in July of 1992 and culminated in the launch of the drug in the United States in June of 1999. Nonsteroidal antiinflammatory drugs (NSAIDs) have long been
Michael J. Gresser, Alan Nies
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Publisher Summary This chapter deals with aspects of the discovery and development of Cyclooxygenase-2 (Cox-2) inhibitors, which, in the case of rofecoxib, resulted from efforts that were initiated in July of 1992 and culminated in the launch of the drug in the United States in June of 1999. Nonsteroidal antiinflammatory drugs (NSAIDs) have long been
Michael J. Gresser, Alan Nies
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Cyclooxygenase inhibitors: any reservations?
Internal Medicine Journal, 2001AbstractThe discovery of two cyclooxygenase isozymes, constitutive COX‐1 and inducible COX‐2, has resulted in the rapid development of selective inhibitors of COX‐2, such as celecoxib and rofecoxib. Compared with traditional non‐steroidal anti‐inflammatory drug agents, use of COX‐2 selective inhibitors is associated with decreased incidence of adverse ...
Penglis, P., James, M., Cleland, L.
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Journal of Medicinal Chemistry, 1997
A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo.
T. Penning +22 more
semanticscholar +1 more source
A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo.
T. Penning +22 more
semanticscholar +1 more source
Cyclooxygenase-2 selective inhibitors
Drugs of Today, 1999The identification of two cyclooxygenase (COX) enzymes has been a tremendous advance in understanding the role of prostaglandins in inflammation and the actions of nonsteroidal antiinflammatory drugs (NSAIDs). COX-1 activity appears to be related to "constitutive" or "housekeeping" functions in the gastric mucosa, kidney and platelets.
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Cyclooxygenase-2 inhibitors in colorectal cancer
Seminars in Oncology, 2003Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key positions in important physiologic processes such as immunity, reproduction, and vascular integrity. Large retrospective and prospective population-based studies have shown that the use of both nonselective, nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors ...
Jan Stoehlmacher, Heinz-Josef Lenz
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