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Selective Cyclooxygenase-2 Inhibitors
2004Publisher Summary Cyclooxygenase (prostaglandin G/H synthase) catalyzes the conversion of arachidonic acid (AA) into prostaglandin H2 as the first committed step of prostaglandin biosynthesis. This enzyme is known to be the target of acetyl salicylic acid (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs).
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[Pharmacology and classification of cyclooxygenase inhibitors].
Gastroenterologie clinique et biologique, 2004The discovery of at least two cyclooxygenase (COX) isoenzymes had two major consequences: i) to give a new impetus to the research on lipid metabolism, giving rise to the crystallization of these peculiar membrane enzymes, the characterization of their active sites and their gene regulation, and the identification of new metabolic pathways; ii) the ...
Jouzeau, Jean-Yves +3 more
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[Coxibs: cyclooxygenase-2 inhibitors].
Wiener klinische Wochenschrift, 2001The oxygenating enzyme cyclooxygenase (COX) catalysis the conversion of arachidonic acid to proinflammatory prostaglandins. For many years it was thought that COX is a single enzyme that is present constitutively in most tissues. But in the late 80ies COX activity was found to be increased in inflammatory states with cytokines and bacterial ...
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Correction: Cyclooxygenase-2 Inhibitors
Annals of Pharmacotherapy, 1999Barbara Kaplan-Machlis +1 more
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