Results 161 to 170 of about 31,862 (193)

Functional aspects of extracellular cyclophilins

Biological Chemistry, 2014
Abstract The cyclophilin family of peptidyl prolyl cis/trans isomerases includes several isoforms found to be secreted in response to different stimuli, thus existing both in the interior and the exterior of cells. The extracellular fractions of the cyclophilins CypA and CypB are involved in the control of cell-cell communication.
Henrik, Hoffmann, Cordelia, Schiene-Fischer   +1 more
openaire   +2 more sources

Role of Cyclophilin A in HIV Replication

Future Virology, 2006
A review. More than a decade has passed since the discovery that the peptidyl prolyl isomerase cyclophilin A (CypA) specifically binds to a proline-rich sequence in HIV-1 capsid (CA) and is thereby incorporated into viral particles. Since then, a variety of possible functions of CypA in the HIV-1 replication cycle have been intensively investigated ...
Votteler, J., Wray, V., Schubert, U.S.
openaire   +2 more sources

Cyclophilin D as a Drug Target

Current Medicinal Chemistry, 2003
The mitochondrial permeability transition (MPT) plays an important role in damage-induced cell death, and agents inhibiting the MPT may have a therapeutic potential for treating human conditions such as ischemia/reperfusion injury, trauma, and neurodegenerative diseases.
Peter C, Waldmeier, Kaspar, Zimmermann, Ting, Qian, Marina, Tintelnot-Blomley, John J, Lemasters   +4 more
openaire   +2 more sources

Redox regulation of cyclophilin A by glutathionylation

PROTEOMICS, 2006
AbstractUsing redox proteomics techniques to characterize the thiol status of proteins in human T lymphocytes, we identified cyclophilin A (CypA) as a specifically oxidized protein early after mitogen activation. CypA is an abundantly expressed cytosolic protein, target of the immunosuppressive drug cyclosporin A (CsA), for which a variety of functions
Ghezzi, Pietro, Casagrande, Simona, Massignan, Tania, Basso, Manuela, Bellacchio, Emanuele, Mollica, Luca, Biasini, Emiliano, Tonelli, Rossella, Eberini, Ivano, Gianazza, Elisabetta, Dai, Wei Wei, Fratelli, Maddalena, Salmona, Mario, Sherry, Barbara, Bonetto, Valentina   +14 more
openaire   +2 more sources

Role of cyclophilin a during oncogenesis

Archives of Pharmacal Research, 2010
Cyclophilins (Cyps) are ubiquitously expressed proteins that are evolutionarily conserved. CypA is the most abundant among the Cyps and is expressed in the cytosol. With its chaperone and PPIase activities, CypA contributes to the maintenance of correct conformation of nascent or denatured proteins and also provides protection against environmental ...
openaire   +2 more sources

Cyclophilin A as a Target of Cisplatin Chemosensitizers

Current Cancer Drug Targets, 2014
Platinum-based chemotherapeutics are the mainstay of treatment of a range of tumors achieving high response rates but limited in the course of disease by appearance of drug resistance. Tumor cells respond with reduced uptake and increased intracellular inactivation of the drugs, as well as increased DNA repair and general resistance to ...
openaire   +2 more sources

Cyclophilin Inhibitors

Current Hepatitis Reports, 2012
Robert Flisiak, Anna Parfieniuk-Kowerda
openaire   +1 more source

Cyclophilin

Science-Business eXchange, 2014
openaire   +1 more source

Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells

EMBO Journal, 2001
Douglas Braaten, Jeremy Luban
exaly  

Cyclophilin A Is Secreted by a Vesicular Pathway in Vascular Smooth Muscle Cells

Circulation Research, 2006
Tetsuya Matoba, Bradford C Berk
exaly