Results 61 to 70 of about 827 (152)

Properties of the Permeability Transition of Pea Stem Mitochondria

Frontiers in Physiology, 2018
In striking analogy with Saccharomyces cerevisiae, etiolated pea stem mitochondria did not show appreciable Ca2+ uptake. Only treatment with the ionophore ETH129 (which allows electrophoretic Ca2+ equilibration) caused Ca2+ uptake followed by increased ...
Valentina De Col, Elisa Petrussa, Valentino Casolo, Enrico Braidot, Giovanna Lippe, Antonio Filippi, Carlo Peresson, Sonia Patui, Alberto Bertolini, Valentina Giorgio, Vanessa Checchetto, Angelo Vianello, Paolo Bernardi, Marco Zancani   +13 more
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies

Cancer Science, EarlyView.
ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley   +1 more source

Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.

PLoS ONE, 2015
Human cytomegalovirus uses a variety of mechanisms to evade immune recognition through major histocompatibility complex class I molecules. One mechanism mediated by the immunoevasin protein US2 causes rapid disposal of newly synthesized class I molecules
Daniel C Chapman, Pawel Stocki, David B Williams   +2 more
doaj   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Cotton Bollworm (H. armigera) Effector PPI5 Targets FKBP17‐2 to Inhibit ER Immunity and JA/SA Responses, Enhancing Insect Feeding

Advanced Science
The cotton bollworm causes severe mechanical damage to plants during feeding and leaves oral secretions (OSs) at the mechanical wounds. The role these OSs play in the invasion of plants is still largely unknown. Here, a novel H.
Yaxin Wang, Chuanying Zhu, Gefei Chen, Xuke Li, Mingjv Zhu, Muna Alariqi, Amjad Hussian, Weihua Ma, Keith Lindsey, Xianlong Zhang, Xinhui Nie, Shuangxia Jin   +11 more
doaj   +1 more source

Leaf Structure and Hormonal Balance Modulate Host‐Specificity and Pathogenicity of Botrytis cinerea

Plant, Cell &Environment, EarlyView.
ABSTRACT Botrytis cinerea, a highly successful necrotrophic fungal plant pathogen, demonstrates a remarkably broad host range, yet the precise factors governing its host specificity and its ability to coexist non‐pathogenically with plants remain unclear. This study systematically assessed host preference in a series of B. cinerea agricultural isolates,
Gautam Anand, Chen Benoni, Meirav Leibman‐Markus, Rupali Gupta, Iftah Marash, Loida Tejada, Tali Dolgov, Dalia Rav‐David, Ondřej Plíhal, Ondřej Novák, Maya Kleiman, Yigal Elad, Maya Bar   +12 more
wiley   +1 more source

Editorial: Peptidyl-prolyl cis/trans isomerases (PPIases) in host-pathogen interactions

Frontiers in Cellular and Infection Microbiology, 2022
Michael Steinert
doaj   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Extracellular cyclophilins in health and disease

Biochimica et Biophysica Acta (BBA) - General Subjects, 2015
Extracellular cyclophilins (eCyPs) are pro-inflammatory factors implicated in pathogenesis of a number of inflammatory diseases. Most pathogenic activities of eCyPs are related to their chemotactic action towards leukocytes, which is mediated by eCyP receptor on target cells, CD147, and involves peptidyl-prolyl cis-trans isomerase activity of ...
openaire   +2 more sources