Results 61 to 70 of about 31,862 (193)

Properties of the Permeability Transition of Pea Stem Mitochondria

Frontiers in Physiology, 2018
In striking analogy with Saccharomyces cerevisiae, etiolated pea stem mitochondria did not show appreciable Ca2+ uptake. Only treatment with the ionophore ETH129 (which allows electrophoretic Ca2+ equilibration) caused Ca2+ uptake followed by increased ...
Valentina De Col, Elisa Petrussa, Valentino Casolo, Enrico Braidot, Giovanna Lippe, Antonio Filippi, Carlo Peresson, Sonia Patui, Alberto Bertolini, Valentina Giorgio, Vanessa Checchetto, Angelo Vianello, Paolo Bernardi, Marco Zancani   +13 more
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, EarlyView.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source

Extracellular cyclophilins in health and disease

Biochimica et Biophysica Acta (BBA) - General Subjects, 2015
Extracellular cyclophilins (eCyPs) are pro-inflammatory factors implicated in pathogenesis of a number of inflammatory diseases. Most pathogenic activities of eCyPs are related to their chemotactic action towards leukocytes, which is mediated by eCyP receptor on target cells, CD147, and involves peptidyl-prolyl cis-trans isomerase activity of ...
openaire   +2 more sources

Cyclophilins: Proteins in search of function [PDF]

Plant Signaling & Behavior, 2013
Cyclophilins constitute a subgroup of large family of proteins called immunophilins, which also include FKBPs and Parvulins. They are remarkably conserved in all genera, highlighting their pivotal role in important cellular processes. Most cyclophilins display PPIase enzymatic activity, multiplicity, diverse cellular locations and active role in ...
Kumari, Sumita, Roy, Suchismita, Singh, Prabhjeet, Singla-Pareek, Sneh L., Pareek, Ashwani   +4 more
openaire   +2 more sources

Neutrophil Secretory Proteins Inhibit Calcium Oxalate Crystallisation and Crystal Growth, but Promote Crystal Aggregation

Immunology, EarlyView.
Calcium oxalate monohydrate (COM) crystals cause changes in the secretion of 29 proteins from neutrophil‐like cells, including those involved in neutrophil immune activation and intracellular metabolic adaptation. The neutrophil secreted proteins (secretome) also inhibit calcium oxalate crystallisation and crystal growth, but promote crystal ...
Chanettee Lertprapai, Paleerath Peerapen, Visith Thongboonkerd   +2 more
wiley   +1 more source

Cotton Bollworm (H. armigera) Effector PPI5 Targets FKBP17‐2 to Inhibit ER Immunity and JA/SA Responses, Enhancing Insect Feeding

Advanced Science
The cotton bollworm causes severe mechanical damage to plants during feeding and leaves oral secretions (OSs) at the mechanical wounds. The role these OSs play in the invasion of plants is still largely unknown. Here, a novel H.
Yaxin Wang, Chuanying Zhu, Gefei Chen, Xuke Li, Mingjv Zhu, Muna Alariqi, Amjad Hussian, Weihua Ma, Keith Lindsey, Xianlong Zhang, Xinhui Nie, Shuangxia Jin   +11 more
doaj   +1 more source

Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.

PLoS ONE, 2015
Human cytomegalovirus uses a variety of mechanisms to evade immune recognition through major histocompatibility complex class I molecules. One mechanism mediated by the immunoevasin protein US2 causes rapid disposal of newly synthesized class I molecules
Daniel C Chapman, Pawel Stocki, David B Williams   +2 more
doaj   +1 more source

Piscirickettsiosis in Farmed Turbot, Scophthalmus maximus

Journal of Fish Diseases, EarlyView.
ABSTRACT Piscirickettsia salmonis is a well‐established intracellular pathogen of farmed Atlantic salmon around the world. The bacterium has also been detected from a number of other hosts including lumpfish (Cyclopterus lumpus), seabass (Dicentrarchus labrax) and rainbow trout (Oncorhynchus mykiss).
Hanne K. Nilsen, Magne Kjerulf Hansen, Raoul Kuiper, Jan Inge Øvrebø, Kjersti Sturød, Maryam Saghafian, Snorre Gulla, Anne Berit Olsen, Duncan J. Colquhoun, Ole Bendik Dale   +9 more
wiley   +1 more source