Results 31 to 40 of about 154,825 (291)
Cancer Communications, Volume 42, Issue 12, Page 1288-1313, December 2022., 2022 Abstract Soft‐tissue sarcomas (STS) represent a group of rare and heterogeneous tumors associated with several challenges, including incorrect or late diagnosis, the lack of clinical expertise, and limited therapeutic options. Digital pathology and radiomics represent transformative technologies that appear promising for improving the accuracy of ...
Amandine Crombé +2 more
wiley +1 more source
Blended Survival Curves: A New Approach to Extrapolation for Time-to-Event Outcomes from Clinical Trial in Health Technology Assessment [PDF]
arXiv, 2022 Background Survival extrapolation is essential in the cost-effectiveness analysis to quantify the lifetime survival benefit associated with a new intervention, due to the restricted duration of randomized controlled trials (RCTs). Current approaches of extrapolation often assume that the treatment effect observed in the trial can continue indefinitely,
arxiv
Cancer Communications, Volume 42, Issue 12, Page 1387-1402, December 2022., 2022 Abstract Background Patients with refractory or relapsed acute myeloid leukemia (AML) have poor survival, necessitating the exploration of optimized therapeutic strategy. Here, we aimed to investigate clinical outcomes and health‐related quality of life (HR‐QoL) after total therapy, which included allogeneic hematopoietic stem cell transplantation ...
Chen‐hua Yan +13 more
wiley +1 more source
Evaluation of histological changes induced by prednisolone and cyclophosphamide in some organs of male albino mice [PDF]
Iraqi Journal of Veterinary Sciences, 2022 Prednisolone is a synthetic corticosteroid used to treat various diseases. It is known to be used to treat many conditions such as autoimmune diseases and asthma.
Sahar A AL-Sharqi +2 more
doaj +1 more source
Identifying mechanisms driving the early response of triple negative breast cancer patients to neoadjuvant chemotherapy using a mechanistic model integrating in vitro and in vivo imaging data [PDF]
arXiv, 2022 Neoadjuvant chemotherapy (NAC) is a standard-of-care treatment for locally advanced triple negative breast cancer (TNBC) before surgery. The early assessment of TNBC response to NAC would enable an oncologist to adapt the therapeutic plan of a non-responding patient, thereby improving treatment outcomes while preventing unnecessary toxicities.
arxiv
Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts—A follow‐up
Cancer Medicine, Volume 11, Issue 24, Page 4743-4755, December 2022., 2022 This paper provides an overview of the extramedullary plasmacytoma cases reported between 1999 and 2021. The global patients’ cohort and the current therapy options are compared to our previous report from 1999. Abstract Background Extramedullary plasmacytoma (EMP) is a solitary tumor consisting of neoplastic plasma cells, with very little to no bone ...
Adrian Holler +7 more
wiley +1 more source
Cancer Medicine, Volume 11, Issue 24, Page 4889-4899, December 2022., 2022 This analysis assessed safety and efficacy of lisocabtagene maraleucel (liso‐cel), an autologous CD‐19‐directed CAR T‐cell product, in Japanese patients with R/R aggressive LBCL in Cohort 3 of TRANSCEND WORLD (NCT03484702). Liso‐cel demonstrated meaningful efficacy and a manageable safety profile in Japanese patients with R/R LBCL.
Shinichi Makita +11 more
wiley +1 more source
Food and Agricultural Immunology, 2021 Houttuynia cordata fermented drinks (HCFDs) are dietary liquid supplements widely marketed and consumed for immune enhancement. In this study, the acute oral toxicity and immunostimulatory activity of the selected lyophilized HCFD in healthy and ...
Suppawit Utaiwat +6 more
doaj +1 more source
Cancer, Volume 129, Issue 2, Page 255-263, 15 January 2023., 2023 Abstract Background Autologous anti‐CD19 chimeric antigen receptor (CAR) T‐cell therapy is an effective treatment for approximately 40% of relapsed/refractory large B cell lymphomas (LBCL), and early identification of patients at risk for relapse or progression after CAR T‐cell therapy represents a clinical need.
Anna Guidetti +14 more
wiley +1 more source
Long-Term Cyclophosphamide Treatment in a Case with Serpiginous Choroiditis
Case Reports in Ophthalmology, 2010 Purpose: To report the effect of long-term therapy with the alkylating agent cyclophosphamide in a case with serpiginous choroiditis and thus to contribute to the previously reported few cases showing the beneficial effect of long-term cyclophosphamide ...
Ozlem G. Sahin
doaj +1 more source