Results 51 to 60 of about 257,683 (336)

Glial Fibrillary Acidic Protein Astrocytopathy Based on a Two‐Center Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glial fibrillary acidic protein astrocytopathy (GFAP‐A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP‐A cohort from two centers in China.
Ti Wu, Hao Zhang, Chao Gao, Qiuhua Yu, Moli Fan, Lin‐Jie Zhang, Haipeng Zhang, Hengri Cong, Yuzhen Wei, Chotima Böttcher, Alexej Verkhratsky, Friedemann Paul, Fu‐Dong Shi, Tian Song   +13 more
wiley   +1 more source

Cyclophosphamide versus placebo in scleroderma lung disease.

New England Journal of Medicine, 2006
BACKGROUND We conducted a double-blind, randomized, placebo-controlled trial to determine the effects of oral cyclophosphamide on lung function and health-related symptoms in patients with evidence of active alveolitis and scleroderma-related ...
D. Tashkin, R. Elashoff, P. Clements, J. Goldin, Michael D. Roth, Daniel E. Furst, E. Arriola, R. Silver, C. Strange, M. Bolster, J. Seibold, David J. Riley, V. Hsu, J. Varga, Dean E. Schraufnagel, A. Theodore, R. Simms, R. Wise, F. Wigley, B. White, V. Steen, C. Read, Maureen D Mayes, E. Parsley, K. Mubarak, M. Connolly, J. Golden, M. Olman, B. Fessler, N. Rothfield, M. Metersky   +30 more
semanticscholar   +1 more source

High‐Efficacy Treatment in Neuromyelitis Optica Specturm Disorder Patients With Seropositive AQP4 Antibodies—A Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To compare the effectiveness of high‐efficacy treatments (HET) and low‐efficacy treatments (LET) in NMOSD patients with anti‐aquaporin‐4 antibodies (AQP4‐ab). Methods In this multi‐center study, we analyzed 183 AQP4‐ab seropositive NMOSD patients who received immunosuppressive treatments (IST).
Xiang Li, Binbin Xue, Jia Li, Dewei Xie, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Xu Zhang, Junhui Xia, Jie Lin   +10 more
wiley   +1 more source

Acute Hyponatremia Complicated with Seizure after Adjuvant Chemotherapy with Cyclophosphamide and Epirubicin in a Breast Cancer Patient

Journal of Cancer Research and Practice, 2015
Cyclophosphamide is a widely-used alkylating agent with cytotoxic effects, as well as an immunosuppressive agent. In the past, life-threatening hyponatremia had been reported as a rare complication induced by both high-dose and low-dose cyclophosphamide.
Yun-Chu Lin, Dwan-Ying Chang
doaj   +1 more source

Treatment with Subcritical Water-Hydrolyzed Citrus Pectin Ameliorated Cyclophosphamide-Induced Immunosuppression and Modulated Gut Microbiota Composition in ICR Mice

Molecules, 2020
Subcritical water can effectively hydrolyze pectin into smaller molecules while still maintaining its functional regions. Pectic heteropolysaccharide can mediate immune regulation; however, the possible effects of subcritical water-hydrolyzed citrus ...
Jianbing Chen, Chengcheng Zhang, Qile Xia, Daqun Liu, Xinghe Tan, Yingdi Li, Yan Cao   +6 more
doaj   +1 more source

Phthalimide Analogs Enhance Genotoxicity of Cyclophosphamide and Inhibit Its Associated Hypoxia

Frontiers in Chemistry, 2022
Cyclophosphamide (CP) is a mutagen that is used in cancer chemotherapy, due to its genotoxicity and as an immunosuppressive agent. Thalidomide (TH) is another cancer chemotherapeutic drug.
Amira M. Gamal-Eldeen, Amira M. Gamal-Eldeen, Hussein S. Agwa, Magdy A.-H. Zahran, Bassem M. Raafat, Sherien M. El-Daly, Sherien M. El-Daly, Hamsa J. Banjer, Mazen M. Almehmadi, Afaf Alharthi, Nahed M. Hawsawi, Fayez Althobaiti, Fayez Althobaiti, Mona A. M. Abo-Zeid, Mona A. M. Abo-Zeid   +14 more
doaj   +1 more source

Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.

Journal of the American Medical Association (JAMA), 2014
IMPORTANCE High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small phase 2 trials.
J. V. van Laar, D. Farge, J. Sont, K. Naraghi, Z. Marjanovic, J. Larghero, A. Schuerwegh, E. Marijt, M. Vonk, A. Schattenberg, M. Matucci-Cerinic, A. Voskuyl, A. A. van de Loosdrecht, T. Daikeler, I. Kötter, M. Schmalzing, T. Martin, B. Lioure, S. Weiner, A. Kreuter, C. Deligny, J. Durand, P. Emery, K. Machold, F. Sarrot-Reynauld, K. Warnatz, D. Adoue, J. Constans, H. Tony, N. Del Papa, A. Fassas, A. Himsel, D. Launay, A. Lo Monaco, P. Philippe, I. Quéré, É. Rich, R. Westhovens, B. Griffiths, R. Saccardi, F. V. D. van den Hoogen, W. Fibbe, G. Socié, A. Gratwohl, A. Tyndall   +44 more
semanticscholar   +1 more source

Exploring if Longitudinal Changes on PET Imaging Can Serve as a Biomarker for Stiff Person Syndrome Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabolic activity as a surrogate for treatment response.
Munther M. Queisi, Samantha N. Roman, Mohammad S. Sadaghiani, Lilja B. Solnes, Scott D. Newsome   +4 more
wiley   +1 more source

Vinorelbine, cyclophosphamide and 5-FU effects on the circulating and intratumoural landscape of immune cells improve anti-PD-L1 efficacy in preclinical models of breast cancer and lymphoma

British Journal of Cancer, 2018
Anti-PD-1 and anti-PD-L1 checkpoint inhibitors (CIs) are clinically active in many types of cancer. However, only a minority of patients achieve a complete and/or long-lasting clinical response.
S. Orecchioni, G. Talarico, V. Labanca, A. Calleri, P. Mancuso, F. Bertolini   +5 more
semanticscholar   +1 more source

Improving Documentation Rates of Contraception and Reproductive Planning in Patients With Rheumatic Disease

Arthritis Care &Research, EarlyView.
Objective This study aimed to improve contraception and reproductive planning documentation within rheumatology providers’ notes at a single academic center. Methods Female patients aged 18 to 45 years with autoimmune inflammatory rheumatic diseases were identified, and chart review was performed for documentation of contraception and pregnancy ...
Benjamin Moon, Puneet Bajaj, Megan Clowse, James Roberts, Kathryn Dao, Bonnie L. Bermas, Brooke S. Mills   +6 more
wiley   +1 more source