Results 61 to 70 of about 5,138 (211)

In Vitro Chemopreventive Properties of Green Tea, Rooibos and Honeybush Extracts in Skin Cells

Molecules, 2016
The chemopreventive properties of the herbal teas rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) have been demonstrated on mouse skin in vivo but the underlying mechanisms are not clear. The aim of the current study was to determine the anti-
Tandeka U. Magcwebeba, Pieter Swart, Sonja Swanevelder, Elizabeth Joubert, Wentzel C. A. Gelderblom   +4 more
doaj   +1 more source

Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma [PDF]

, 2012
Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40% of all cancers in the United States with a growing incidence rate in the last decades in all developed countries.
CUCCHI, DANILO, DE SMAELE, Enrico, GULINO, Alberto, OCCHIONE, MARIA ANNA   +3 more
core   +3 more sources

Multi‐Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This review shows evidence from preclinical and clinical studies, supporting the therapeutic potential of polyphenols for diabetic kidney disease (DKD). This is due to their diverse bioactive properties and ability to intervene in intricate mechanisms of the disease.
Esienanwan E. Efiong, Emmanuel Effa, Esther Peters, Ochuko L. Erukainure, Peter U. Amadi, Joshua Onyeka Ikebuiro, Sapna Sharma, Christoph Schmaderer, Kathrin Maedler, Emmy Tuenter, Harald Grallert   +10 more
wiley   +1 more source

Development of astrocytes in the vertebrate eye [PDF]

, 2014
Astrocytes represent the earliest glial population in the embryonic optic nerve, contributing critically to retinal angiogenesis and formation of brain-retinal-barrier.
Tao, Chenqi, Zhang, Xin
core   +1 more source

Exome Sequencing Reveals the Genetic Architecture of Non‐syndromic Orofacial Clefts and Identifies BOC as a Novel Causal Gene

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He, Min Yu, Yuhua Jiao, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou, Zhanping Ren, Beile Lyu, Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang, Chunyan Yin, Huaxiang Zhao, Yi Ding   +16 more
wiley   +1 more source

Histogenesis of retinal dysplasia in trisomy 13

Diagnostic Pathology, 2007
Background Although often associated with holoprosencephaly, little detail of the histopathology of cyclopia is available. Here, we describe the ocular findings in a case of trisomy 13 to better understand the histogenesis of the rosettes, or tubules ...
Gonzalez-Fernandez Federico, Heffner Reid, Lakshminrusimha Satyan, Chan Ada   +3 more
doaj   +1 more source

Proboscis Lateralis : A Rare Bilateral Case in Association with Holoprosencephaly [PDF]

Journal of Clinical and Diagnostic Research, 2015
Proboscis lateralis is a very rare congenital craniofacial malformation characterized by a trunk like tubular appendage arising commonly from roof of the orbit near medial canthus.
Vasavi Kolluru, Sendhil Coumary
doaj   +1 more source

Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway.

PLoS ONE, 2020
Pericellular and extracellular proteoglycans play an important role in modulating morphogen gradients and signal transductions. Chondroitin sulfate proteoglycan 4 (Cspg4) is a membrane spanning proteoglycan expressed in immature progenitor cells and ...
Yen-Hua Lee, Koichi Kawakami, Wei-Chun HuangFu, I-Hsuan Liu   +3 more
doaj   +1 more source

Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. [PDF]

, 2018
The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown,
A Dagklis, A Dagklis, A El Andaloussi, A Gutierrez, A Sekulic, AA Ferrando, AE Place, AK Fielding, AL Furmanski, AM Kenney, C Reynolds, CH Pui, CJ Neumann, DD Hoff Von, DI Marks, DM Stone, DV Catenacci, E Drakopoulou, E Lindstrom, GW Robinson, H Hahn, H Hahn, HA Zahreddine, HJ Sharpe, I Hofmann, J Briscoe, J Chen, J Gao, J Rodon, J Taipale, JM Goldberg, JS Blackburn, JY Tang, KD Robarge, LV Goodrich, M Aszterbaum, M Duman-Scheel, M Sadelain, M Schrappe, MJ Koudijs, NJ Rowbotham, PD Bhola, PD Stenson, PL So, PM LoRusso, RH Ko, RL Johnson, S Hettmer, SB Kaye, SP Hunger, SS Winter, SV Outram, T Ni Chonghaile, TT Vo, Y Liu   +54 more
core   +1 more source

Transforming growth factor‐β‐mediated regulation of atoh1‐expressing neural progenitors is involved in the generation of cerebellar granule cells in larval and adult zebrafish

Development, Growth &Differentiation, Volume 67, Issue 3, Page 149-164, April 2025.
Proliferating neural progenitor cells that generate granule cells are located in the molecular layer (ML) of the cerebellum. Among these, some atoh1c‐expressing cells begin to differentiate and migrate to the granular layer (GL), where they localize as mature granule cells.
Jui Chun Wang, Takashi Shimizu, Masahiko Hibi   +2 more
wiley   +1 more source